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Green Synthesis of Hydroxyapatite Nanoparticles with Controlled Morphologies and Surface Properties Toward Biomedical Applications

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Many attempts have been conducted for green synthesis of biofunctional scaffolds and implant coatings. Hydroxyapatite Ca5(OH)(PO4)3 (HA), is an excellent material for these purposes. HA is a major mineral component of vertebrate bones and teeth; it constitutes 70 wt% of human bones. This paper reports on the sustainable fabrication of HA particles in different morphologies including nanoplates (400 nm L and 150 nm W), and nanorods (10 nm D and 500 nm L). XRD diffractogram revealed highly crystalline structure. HA nanoplates were surface modified with poly(ethylene-co-AA) polymeric surfactant; organic modified HA nanoplates demonstrated complete change in surface properties from hydrophilic to hydrophobic. It demonstrated effective phase transfer from aqueous phase to organic phase, with decrease in nanoplate size to 100 nm L, 50 nm W. Layered HA plates were further developed via surface modification with dodecanedioic acid; this approach can offer laminated or exfoliated plates for effective integration into bio-compatible polymers. This manuscript shaded the light on facile green synthesis of HA nanoparticles with controlled morphology and surface properties.

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Correspondence to Sherif Elbasuney.

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Elbasuney, S. Green Synthesis of Hydroxyapatite Nanoparticles with Controlled Morphologies and Surface Properties Toward Biomedical Applications. J Inorg Organomet Polym 30, 899–906 (2020). https://doi.org/10.1007/s10904-019-01247-4

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  • Hydrothermal synthesis
  • Hydroxyapatitie
  • Artificial bones
  • Dental tissues