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Synthesis, Crystal Structures and Anti-lung Cancer Effects of Two Copper(II) Coordination Polymers Mediated by Mitochondrial-Dependent Apoptosis

  • Chun-Mei Hu
  • Wei Zhong
  • Yan Tang
  • Qiong Yu
  • Guang ShiEmail author
Article
  • 16 Downloads

Abstract

In this study, two new Cu(II)-based coordination polymers {[Cu2(pdc)2](DMF)2}n (1, H2pdc = pyridine-3,5-bis(phenyl-4-carboxylic) acid) and {[Cu2(ndc)2(bpee)2]2.5H2O}n (2, H2ndc = 1,2-naphthalenedicarboxylic acid, bpee = trans-1,2-bis(4-pyridyl)ethylene) have been successfully prepared under different solvothermal conditions. In addition, the anti-proliferation activity of compounds 1 and 2 was detected against the human non-small cell lung cancer NCI-H1650 with MTT assay. The cell viability curves and compounds IC50 values indicated that both of these two new synthesized compounds have anti-proliferation activity on NCI-H1650 cells, and compound 1 showed stronger inhibitory effect than compound 2. And then, the LDH detection and Annexin V-FITC/PI assay was used to explore the manner of NCI-H1650 cell death. The intracellular ATP and ROS level was measured to confirm whether the apoptotic cell death was caused in a mitochondrial-dependent manner.

Keywords

Coordination polymers Cytotoxicity Apoptosis Mitochondrial dysfunction Lung cancer 

Notes

Supplementary material

10904_2019_1129_MOESM1_ESM.pdf (186 kb)
Supplementary material 1 (PDF 186 KB)
10904_2019_1129_MOESM2_ESM.pdf (174 kb)
Supplementary material 2 (PDF 174 KB)

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Chun-Mei Hu
    • 1
  • Wei Zhong
    • 2
  • Yan Tang
    • 1
  • Qiong Yu
    • 1
  • Guang Shi
    • 1
    Email author
  1. 1.Department of Hematology and OncologyThe Second Hospital of Jilin UniversityChangchunChina
  2. 2.Department of OphthalmologyChina-Japan Union Hospital of Jilin UniversityChangchunChina

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