Synthesis, Crystal Structures and Anti-lung Cancer Effects of Two Copper(II) Coordination Polymers Mediated by Mitochondrial-Dependent Apoptosis

  • Chun-Mei Hu
  • Wei Zhong
  • Yan Tang
  • Qiong Yu
  • Guang ShiEmail author


In this study, two new Cu(II)-based coordination polymers {[Cu2(pdc)2](DMF)2}n (1, H2pdc = pyridine-3,5-bis(phenyl-4-carboxylic) acid) and {[Cu2(ndc)2(bpee)2]2.5H2O}n (2, H2ndc = 1,2-naphthalenedicarboxylic acid, bpee = trans-1,2-bis(4-pyridyl)ethylene) have been successfully prepared under different solvothermal conditions. In addition, the anti-proliferation activity of compounds 1 and 2 was detected against the human non-small cell lung cancer NCI-H1650 with MTT assay. The cell viability curves and compounds IC50 values indicated that both of these two new synthesized compounds have anti-proliferation activity on NCI-H1650 cells, and compound 1 showed stronger inhibitory effect than compound 2. And then, the LDH detection and Annexin V-FITC/PI assay was used to explore the manner of NCI-H1650 cell death. The intracellular ATP and ROS level was measured to confirm whether the apoptotic cell death was caused in a mitochondrial-dependent manner.


Coordination polymers Cytotoxicity Apoptosis Mitochondrial dysfunction Lung cancer 


Supplementary material

10904_2019_1129_MOESM1_ESM.pdf (186 kb)
Supplementary material 1 (PDF 186 KB)
10904_2019_1129_MOESM2_ESM.pdf (174 kb)
Supplementary material 2 (PDF 174 KB)


  1. 1.
    P.C. Bruijnincx, P.J. Sadler, Curr. Opin. Chem. Biol. 12, 197–206 (2008)CrossRefGoogle Scholar
  2. 2.
    S.H. van Rijt, P.J. Sadler, Drug Discov. Today 14, 1089–1097 (2009)CrossRefGoogle Scholar
  3. 3.
    R.S. Wang, J. Feng, Y.Z. Lei, D.M. Chen, M.L. Lian, Cryst. Res. Technol. 53, 1800065 (2018)CrossRefGoogle Scholar
  4. 4.
    C.W. Duan, L.X. Hu, J.L. Ma, J. Mater. Chem. A 6, 6309–6318 (2018)CrossRefGoogle Scholar
  5. 5.
    Y. Feng, H. Fan, Z. Zhong, H. Wang, D. Qiu, Inorg. Chem. 55, 11987–11992 (2016)CrossRefGoogle Scholar
  6. 6.
    Y. Feng, M. Li, H. Fan, Q. Huang, D. Qiu, H. Shi, Dalton Trans. 44, 894–897 (2015)CrossRefGoogle Scholar
  7. 7.
    C.W. Duan, Y.Z. Cao, L.X. Hu, D. Fu, J.L. Ma, Mater. Lett. 238, 254–257 (2019)CrossRefGoogle Scholar
  8. 8.
    K. Wu, K. Du, G. Hu, J. Mater. Chem. A 6, 1057–1066 (2018)CrossRefGoogle Scholar
  9. 9.
    K. Yin, S. Yang, X.R. Dong, D.K. Chu, J.A. Duan, J. He, Appl. Phys. Lett. 112, 243701 (2018)CrossRefGoogle Scholar
  10. 10.
    D.M. Chen, W. Shi, P. Cheng, Chem. Commun. 51, 370–372 (2015)CrossRefGoogle Scholar
  11. 11.
    C. Janiak, Dalton Trans. 51, 2781 (2003)CrossRefGoogle Scholar
  12. 12.
    S. Shen, Y. Wu, K. Li, Y. Wang, J. Wu, Y. Zeng, D. Wu, Biomaterials 154, 197–212 (2018)CrossRefGoogle Scholar
  13. 13.
    J.F. Eubank, L. Wojtas, M.R. Hight, T. Bousquet, V.C. Kravtsov, M. Eddaoudi, J. Am. Chem. Soc. 133, 17532–17535 (2011)CrossRefGoogle Scholar
  14. 14.
    C. Heering, I. Boldog, V. Vasylyeva, J. Sanchiz, C. Janiak, CrystEngComm 15, 9757 (2013)CrossRefGoogle Scholar
  15. 15.
    S. Su, W. Chen, X. Song, M. Zhu, C. Qin, S. Song, Z. Guo, S. Wang, Z. Hao, G. Li, H. Zhang, CrystEngComm 14, 1681–1686 (2012)CrossRefGoogle Scholar
  16. 16.
    Y.H. Zhao, H.B. Xu, Y.M. Fu, K.Z. Shao, S.Y. Yang, Z.M. Su, X.R. Hao, D.X. Zhu, E.B. Wang, Cryst. Growth Des. 8, 3566–3576 (2008)CrossRefGoogle Scholar
  17. 17.
    P. Ayyappan, O.R. Evans, Y. Cui, K.A. Wheeler, W. Lin, Inorg. Chem. 41, 4978–4980 (2002)CrossRefGoogle Scholar
  18. 18.
    N. Muhammad, Z. Guo, Curr. Opin. Chem. Biol. 19, 144–153 (2014)CrossRefGoogle Scholar
  19. 19.
    K. Jomova, M. Valko, Toxicology 283, 65–87 (2011)CrossRefGoogle Scholar
  20. 20.
    A.C. Hangan, G. Borodi, R.L. Stan, E. Páll, M. Cenariu, L.S. Oprean, B. Sevastre, Inorg. Chim. Acta 482, 884–893 (2018)CrossRefGoogle Scholar
  21. 21.
    D. Senthil Raja, E. Ramachandran, N.S.P. Bhuvanesh, K. Natarajan, Eur. J. Med. Chem. 64, 148–159 (2013)CrossRefGoogle Scholar
  22. 22.
    C. Marzano, M. Pellei, F. Tisato, C. Santini, Anticancer. Agents Med. Chem. 9, 185–211 (2009)CrossRefGoogle Scholar
  23. 23.
    J. Serment-Guerrero, P. Cano-Sanchez, E. Reyes-Perez, F. Velazquez-Garcia, M.E. Bravo-Gomez, L. Ruiz-Azuara, Toxicol. Vitr. 25, 1376–1384 (2011)CrossRefGoogle Scholar
  24. 24.
    A.T. Chaviara, P.C. Christidis, A. Papageorgiou, E. Chrysogelou, D.J. Hadjipavlou-Litina, C.A. Bolos, J. Inorg. Biochem. 99, 2102–2109 (2005)CrossRefGoogle Scholar
  25. 25.
    X. Lin, D. Tian, Y. Fu, Y. Li, L. Huang, W. Gu, J. Song, Y. Li, Y. Ben-David, M. Wen, C. Yuan, X. Hao, Eur. J. Med. Chem. 162, 765–780 (2018)CrossRefGoogle Scholar
  26. 26.
    A. Antosik, K. Czubak, N. Cichon, P. Nowak, H. Zbikowska, Transfus. Med. Hemoth. 45, 347–354 (2018)CrossRefGoogle Scholar
  27. 27.
    X. Yu, J. Zhao, Y. He, J. BUON 23, 48–54 (2018)Google Scholar
  28. 28.
    M.M.N. Babadaei, M.F. Moghaddam, S. Solhvand, E. Alizadehmollayaghoob, F. Attar, E. Rajabbeigi, K. Akhtari, S. Sari, M. Falahati, Int. J. Nanomed. 13, 6871–6884 (2018)CrossRefGoogle Scholar
  29. 29.
    X. Song, B. Wang, S. Lin, L. Jing, C. Mao, P. Xu, C. Lv, W. Liu, J. Zuo, J. Cell Mol. Med. 18, 2198–2212 (2014)CrossRefGoogle Scholar
  30. 30.
    X. Wang, D. Liu, H. Lin, G. Liu, X. Wang, M. Le, X. Rong, CrystEngComm 18, 888–897 (2016)CrossRefGoogle Scholar
  31. 31.
    H. Abourahma, G.J. Bodwell, J. Lu, B. Moulton, I.R. Pottie, R.B. Walsh, M.J. Zaworotko, Cryst. Growth Des. 3, 513–519 (2003)CrossRefGoogle Scholar
  32. 32.
    K. Nakamoto, Infrared and Raman Spectra of Inorganic and Coordination Compounds (Wiley, New York, 1986)Google Scholar
  33. 33.
    L.P. Dai, C. Li, H.Z. Yang, Y.Q. Lu, H.Y. Yu, H.M. Gao, Z.M. Wang, Molecules 20, 17544–17556 (2015)CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Chun-Mei Hu
    • 1
  • Wei Zhong
    • 2
  • Yan Tang
    • 1
  • Qiong Yu
    • 1
  • Guang Shi
    • 1
    Email author
  1. 1.Department of Hematology and OncologyThe Second Hospital of Jilin UniversityChangchunChina
  2. 2.Department of OphthalmologyChina-Japan Union Hospital of Jilin UniversityChangchunChina

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