Rapid Dilapidation of Alcohol Using Magnesium Oxide and Magnesium Aspartate based Nanostructures: A Raman Spectroscopic and Molecular Simulation Approach
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Magnesium in the form of magnesium sulphate, magnesium oxide, magnesium hydroxide, and magnesium carbonate magnesium was conventionally in use as an effective antidepressant component. However, the concentration of these materials was high, varying from 150 to 500 mg per day. In recent days, nano-formulation of drugs is of high great interest due to its higher performance compare to the bulk structure. In the present work, MgO nanoparticle of size less than 10 nm have been synthesized by the wet chemical method with a sintering condition of 400 °C for 3 h. Magnesium aspartate was prepared from aspartic acid by modifying the prepared MgO nanoparticles. In vitro ethanol dilapidation studies at a various time interval and molecular docking interaction studies of MgO and Magnesium aspartate with NMDA receptors confirm that, these nanostructures compounds are suggestible as supplements for magnesium deficient and alcohol-induced depression.
KeywordsMgO Nanoparticle Aspartate Sol–gel Raman NMDA
One of the authors D. Durgalakshmi gratefully acknowledges DST-INSPIRE Faculty Fellowship under the sanction DST/INSPIRE/04/2016/000845 for their funding. S. Balakumar acknowledges Department of Biotechnology (DBT) for their project funding under the sanction BT/PR8236/NNT/28/669.
Compliance with Ethical Standards
Conflict of interest
The authors declare that they have no conflict of interest.
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