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PLLA/nHA Composite Films and Scaffolds for Medical Implants: In Vitro Degradation, Thermal and Mechanical Properties

  • Esperanza Díaz
  • Ane Libe Molpeceres
  • Iban Sandonis
  • Igor Puerto
Article
  • 20 Downloads

Abstract

Two poly(l-lactide) (PLLA) materials and changes in their mechanical, thermal, physical, and chemical properties while undergoing in vitro degradation are studied. The potential applications of PLLA implants extend to films for controlled drug release systems and biodegradable scaffolds for bone implants (fabricated with thermal induced phase separation) (TIPS) using bioactive nanohydroxyapatite particles. The study was conducted in a phosphate buffer saline (PBS) solution at 37 °C over 8 weeks. Reinforcement with nHA particles increased the elastic modulus and the yield stress, due perhaps to restricted C–C bond rotations and polymer sliding, although that increase was not proportional with the added percentages of nanoparticles. The elastic modulus and the yield stress of the films decreased faster than those of the scaffolds. As from the seventh week some samples could not be tested due to the fragility of the specimens. The scaffolds had a higher enthalpy of fusion than the films, suggesting that crystalline domains formed more easily in the scaffolds than in the films. The films degraded more quickly than the scaffolds, because the acid products resulting from the degradation process were evacuated from the films with greater difficulty than from the scaffolds in which the autocatalytic effect was of greater importance. Porosity was decisive in the rate of degradation.

Keywords

Films Scaffolds In vitro degradation Thermal properties Mechanical properties 

Notes

Acknowledgements

Technical and human support provided by SGIker (UPV/EHU, MICINN, GV/EJ, ERDF, and ESF) are really appreciated.

Author Contributions

ALM, IS, IP and ED conceived and designed the experiments; ALM and IS performed the experiments; ALM, IS, IP and ED analyzed the data; ED contributed reagents/materials/analysis tools; ED wrote the paper.

Compliance with Ethical Standards

Conflict of interest

The authors declare no conflict of interest.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Escuela de Ingeniería de Bilbao, Departamento de Ingeniería Minera, Metalúrgica y Ciencia de MaterialesUniversidad del País Vasco (UPV/EHU)PortugaleteSpain
  2. 2.BCMaterialsLeioaSpain
  3. 3.Escuela de Ingeniería de Bilbao, Departamento de Física Aplicada IUniversidad del País Vasco (UPV/EHU)PortugaleteSpain

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