Synthesis of Organotin Polyamine Ethers Containing Acyclovir and their Preliminary Anticancer and Antiviral Activity

  • Charles E. CarraherJr.
  • Theodore S. Sabir
  • Michael R. Roner
  • Kimberely Shahi
  • Robert E. Bleicher
  • Joanne L. Roehr
  • Kelly D. Bassett
Article

DOI: 10.1007/s10904-006-9050-y

Cite this article as:
Carraher, C.E., Sabir, T.S., Roner, M.R. et al. J Inorg Organomet Polym (2006) 16: 249. doi:10.1007/s10904-006-9050-y

Abstract

Organotin polyamine ethers containing acyclovir in their backbone were synthesized in moderate to high yield employing the aqueous interfacial polycondensation system. The products are high molecular weight polymers. Infrared spectroscopy of the products shows new bands characteristic of the formation of Sn–N and Sn–O bonds consistent with the proposed structure. MALDI-TOF MS below 2000 Da shows the presence of organotin and acyclovir units containing these two moieties. The products show moderate inhibition of a number of cancer cell lines and exhibit the ability to inhibit a number of viruses, particularly the herpes simplex virus-1 and varicella zoster virus that are responsible for herpes, chicken pox and shingles.

Keywords

Organotin polymers acyclovir interfacial polymerization MALDI-TOF MS herpes chicken pox small pox shingles reovirus ST3 HSV-1 viruses viruses bioterrorism VZV virus varicella zoster virus vaccinia WR virus herpes simplex virus anticancer drugs L929 cells 143 cells BS-C-1 cells vero cells 

Copyright information

© Springer Science+Business Media, Inc. 2006

Authors and Affiliations

  • Charles E. CarraherJr.
    • 1
    • 5
  • Theodore S. Sabir
    • 1
    • 2
  • Michael R. Roner
    • 3
  • Kimberely Shahi
    • 3
  • Robert E. Bleicher
    • 4
  • Joanne L. Roehr
    • 3
  • Kelly D. Bassett
    • 3
  1. 1.Department of Chemistry and BiochemistryFlorida Atlantic UniversityBoca RatonUSA
  2. 2.Department of ChemistryProvidence Christian CollegeOntarioUSA
  3. 3.Department of BiologyUniversity of Texas at ArlingtonArlingtonUSA
  4. 4.California State University Channel IslandsCamarilloUSA
  5. 5.Florida Center for Environmental StudiesPalm Beach GardensUSA

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