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Journal of Immigrant and Minority Health

, Volume 15, Issue 6, pp 1023–1029 | Cite as

Both HCV and HBV are Major Causes of Liver Cancer in Southeast Asians

  • Hillary Lin
  • Nghiem B. Ha
  • Aijaz Ahmed
  • Walid Ayoub
  • Tami J. Daugherty
  • Glen A. Lutchman
  • Gabriel Garcia
  • Mindie H. Nguyen
Original Paper

Abstract

The incidence of hepatocellular carcinoma (HCC) is higher in Asian Americans than in other ethnicities. While hepatitis B virus (HBV) is common, hepatitis C virus (HCV) is more prevalent in some subgroups. Our goal was to determine the etiology of liver disease associated with HCC in subgroups of Asian Americans. This was an analysis of 510 Asian HCC patients at a US medical center. Patients were identified using ICD9 diagnosis. Multivariate logistic regression was used to study predictors of HCV as the cause of HCC. Patients were Southeast Asian, Chinese, and Korean, with similar gender, age, and foreign-born status. Southeast Asians had a similar proportion of HBV- and HCV-related HCC, while Chinese and Korean patients had a higher proportion of HBV-related HCC. HCC was usually associated with HBV in Chinese and Korean patients, but both HCV and HBV were important associations in Southeast Asians.

Keywords

Hepatocellular carcinoma Asians Asian Americans Hepatitis C Hepatitis B 

Abbreviations

HCC

Hepatocellular carcinoma

HBV

Hepatitis B virus

HCV

Hepatitis C virus

ALT

Alanine aminotransferase

AST

Aspartate aminotransferase

AFP

Alpha fetoprotein

TNM

Tumor, node, and metastasis stage

BCLC

Barcelona clinic liver cancer stage

NAFLD

Nonalcoholic fatty liver disease

MELD

Model for end-stage liver disease

CTP

Child-Turcotte Pugh

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Hillary Lin
    • 1
  • Nghiem B. Ha
    • 2
    • 3
  • Aijaz Ahmed
    • 2
  • Walid Ayoub
    • 2
  • Tami J. Daugherty
    • 2
  • Glen A. Lutchman
    • 2
  • Gabriel Garcia
    • 2
  • Mindie H. Nguyen
    • 2
  1. 1.Stanford University School of MedicineStanfordUSA
  2. 2.Division of Gastroenterology and Hepatology, Department of MedicineStanford University Medical CenterStanford, Palo AltoUSA
  3. 3.UC Davis School of MedicineSacramentoUSA

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