Journal of Immigrant and Minority Health

, Volume 15, Issue 6, pp 1107–1112

Family History of Prostate Cancer in a Black Population

  • Barbara Nemesure
  • Suh-Yuh Wu
  • Anselm Hennis
  • M. Cristina Leske
Original Paper

DOI: 10.1007/s10903-012-9710-7

Cite this article as:
Nemesure, B., Wu, SY., Hennis, A. et al. J Immigrant Minority Health (2013) 15: 1107. doi:10.1007/s10903-012-9710-7

Abstract

Although family history of prostate cancer (PC) is an established risk factor for the disease, few studies have investigated this relationship among men with an African heritage. The Prostate Cancer in a Black Population (PCBP) study is a large, nationwide case–control study conducted in Barbados, West Indies from 2002 to 2011. In the PCBP study, a family history of PC in fathers or brothers was associated with a threefold increased risk of disease (OR = 3.04, 95 % CI (2.18, 4.22)) and a strong positive relationship was noted for the number of affected first degree relatives. Tumor grade did not generally influence the relationship between family history and PC. The magnitude of risks associated with having a father affected with the disease was slightly higher in the PCBP study compared to other populations. It remains unclear whether this finding is the result of an increased genetic susceptibility in African-Barbadian men.

Keywords

Family history Prostate cancer African ancestry Familial aggregation 

Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Barbara Nemesure
    • 1
  • Suh-Yuh Wu
    • 1
  • Anselm Hennis
    • 1
    • 2
  • M. Cristina Leske
    • 1
  1. 1.Department of Preventive MedicineStony Brook MedicineStony BrookUSA
  2. 2.Chronic Disease Research CentreUniversity of the West Indies and Ministry of HealthBarbadosWest Indies

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