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Treatment Adherence, Meaning in Life and Affects in Quality of Life of HIV/AIDS Patients

  • Ana ReisEmail author
  • Leonor Lencastre
  • Catherina Jonsson
  • Marina Prista GuerraEmail author
Research Paper
  • 12 Downloads

Abstract

The objective of this study is to identify the predictors of the QOL’s domains, specifically, to understand the relationship between biological markers, psychological variables and QOL of HIV/AIDS patients. Cross-sectional developed with 94 individuals with HIV/AIDS, who attend the outpatient clinic specialty and have had an antiretroviral prescription for 3 months. WHOQOL-Bref (QOL), CEAT-VIH (treatment adherence), Meaning in life scale (ML) and PANAS (affects), and sociodemographic and clinical questionnaire. The results of the predictive models of the QOL’s domains, when controlling for the viral load and the CD4 + T cell count, encompass affect balance, treatment adherence and meaning in life with the highest explained variance in the predictive models of QOL in physical 37.4% and psychological 33.9% domains. The affect balance is a predictor of all QOL’s domains and treatment adherence is a predictor of three of them. ML is a predictor of the psychological and environmental domains. This study emphasizes the importance of affect balance, treatment adherence and meaning in life for the QOL in HIV.

Keywords

Quality of life Treatment adherence Meaning in life Affect balance HIV/AIDS 

Notes

Acknowledgements

We wish to thank all the patients who made this study possible.

Funding

This work was funded by the Center for Psychology at the University of Porto, Portuguese Science Foundation (FCT UID/PSI/00050/2019).

References

  1. Audet, C., Wagner, L., & Wallston, K. (2015). Finding meaning in life while living with HIV: validation of a novel HIV meaningfulness scale among HIV-infected participants living in Tennessee. BMC Psychology.  https://doi.org/10.1186/s40359-015-0070-7.CrossRefGoogle Scholar
  2. Balthip, Q. (2010). Achieving harmony of mind: A grounded theory study of people living with HIV/AIDS in the Thai context. Unpublished doctoral dissertation, Massey University, Palmerston North, New Zealand.Google Scholar
  3. Balthip, Q., & Purnell, M. (2014). Pursuing meaning and purpose in life among Thai adolescents living with HIV: A grounded theory study. Journal of the Association of Nurses in AIDS CARE.  https://doi.org/10.1016/j.jana.2014.03.004.CrossRefGoogle Scholar
  4. Beard, J., Feeley, F., & Rosen, S. (2009). Economic and quality of life outcomes of antiretroviral therapy for HIV/AIDS in developing countries: a systematic literature review. AIDS Care, 21(11), 1343–1356.  https://doi.org/10.1080/09540120902889926.CrossRefGoogle Scholar
  5. Cardona-Arias, J. A., & Higuita-Gutierrez, L. F. (2014). Impact of HIV/AIDS on quality of life: Meta-analysis 2002–2012. Revista espanola de salud publica, 88(1), 87–101.  https://doi.org/10.4321/S1135-57272014000100006.CrossRefGoogle Scholar
  6. Centre for Disease Control. (1993). Revised classification system for HIV infection and expanded surveillance case definition for AIDS among adolescents and adults. Retirado de https://www.ncbi.nlm.nih.gov/pubmed/8093740.
  7. Chida, Y., & Vedhara, K. (2009). Adverse psychosocial factors predict poorer prognosis in HIV disease: A meta-analytic review of prospective investigations. Brain, Behavior, and Immunity, 23(4), 434–445.  https://doi.org/10.1016/j.bbi.2009.01.013.CrossRefGoogle Scholar
  8. Ciesla, J. A., & Roberts, J. E. (2001). Meta-analysis of the relationship between HIV infection and risk for depressive disorders. American Journal of Psychiatry, 158, 725–730.CrossRefGoogle Scholar
  9. Cooper, V., Clatworthy, J., Harding, R., Whetham, J., & Emerge Consortium. (2017). Measuring quality of life among people living with HIV: A sistematic review of reviews. Health and Quality of Life Outcomes.  https://doi.org/10.1186/s12955-017-0778-6.CrossRefGoogle Scholar
  10. Degroote, S., Vogelaers, D., & Vandijck, D. M. (2014). What determines health-related quality of life among people living with HIV: An updated review of the literature. Archives of Public Health, 72, 40.  https://doi.org/10.1186/2049-3258-72-40.CrossRefGoogle Scholar
  11. Denvir, M. A., Lee, A. J., Rysdale, J., Walker, A., Eteiba, H., Starkey, I. R., et al. (2006). Influence of socioeconomic status on clinical outcomes and quality of life after percutaneous coronary intervention. Journal of Epidemiology and Community Health, 60, 1085–1088.  https://doi.org/10.1136/jech.2005.044255.CrossRefGoogle Scholar
  12. Fleck, M. A. (2006). O projecto WHOQOL: Desenvolvimentos e aplicações. Psiquiatria Clínica, 27(1), 5–13.Google Scholar
  13. Galinha, I., & Ribeiro, J. P. (2005). Contribuição para o estudo da versão portuguesa da Positive and Negative Affect Schedule (PANAS): II—Estudo psicométrico. Análise Psicológica, 23(2), 219–227.CrossRefGoogle Scholar
  14. Gonzalez, J. S., Batchelder, A., Psaros, C., & Safren, S. A. (2011). Depression and HIV/AIDS treatment nonadherence: A review and meta-analysis. Journal of Acquir Immune Defic Syndr.  https://doi.org/10.1097/qai.0b013822d490a.CrossRefGoogle Scholar
  15. Guerra, M., Lencastre, L., Silva, E., & Teixeira, P. (2017). Meaning in life in medical settings: A new measure correlating with psychological variables in disease. Cogent Psychology, 4, 1286747.  https://doi.org/10.1080/23311908.2017.1286747.CrossRefGoogle Scholar
  16. Heintzelman, S., & King, L. (2014). Life is pretty meaningful. American Psychologist, 69(6), 561–574.CrossRefGoogle Scholar
  17. Jim, H., Purnell, J. Q., Richardson, S. A., Golden-Kreutz, D., & Andersen, B. L. (2006). Measuring meaning in life following cancer. Quality of Life Research, 15(8), 1355–1371.  https://doi.org/10.1007/s11136-00-6-0028-6.CrossRefGoogle Scholar
  18. Koydemir, S., Şimşek, Ö., Schütz, A., & Tipandjan, A. (2013). Differences in how trait emotional intelligence predicts life satisfaction: The role of affect balance versus social support in India and Germany. Journal of Happiness Studies, 14(1), 51–66.CrossRefGoogle Scholar
  19. Li, J., Mo, P., Wu, A., & Lau, J. (2017). Roles of self-stigma, social support, and positive and negative affects as determinants of depressive symptoms among HIV infected men who have sex with men in China. AIDS and Behavior, 21, 261–273.  https://doi.org/10.1007/s10461-016-1321-1.CrossRefGoogle Scholar
  20. Liping, M., Peng, X., Haijiang, L., Lahong, J., & Fan, L. (2015). Quality of life of people living with HIV/AIDS: A cross-sectional study in Zhejiang Province. China: Plos One.  https://doi.org/10.1371/journal.pone.0135705.CrossRefGoogle Scholar
  21. Pallant, J. (2011). SPSS survival manual. Philadelphia: Open University Press.Google Scholar
  22. Parienti, J. J., Bangsberg, D. R., Verdon, R., & Gardner, E. M. (2009). Better adherence with once-daily antiretroviral regimens: A meta-analysis. Clinical Infectious Diseases, 48(4), 484–488.CrossRefGoogle Scholar
  23. Park, N., Park, M., & Peterson, C. (2010). When is the search for meaning related to life satisfaction? Applied Psychology: Health and Well-being, 2, 1–13.Google Scholar
  24. Pinto, C., & Guerra, M. P. (2018). The influence of meaning in life and depression in multiple sclerosis. Análise Psicológica, 4(36), 439–453.  https://doi.org/10.14417/ap1394.CrossRefGoogle Scholar
  25. Reis, A., Guerra, M., & Lencastre, L. (2013a). Treatment adherence, quality of life and clinical variables in HIV/AIDS Infection. World Journal of AIDS, 3(3), 239–250.  https://doi.org/10.4236/wja.2013.33032.CrossRefGoogle Scholar
  26. Reis, A., Guerra, M., & Lencastre, L. (2013b). Treatment adherence and subjective well-being in HIV/AIDS infection. AIDS Care.  https://doi.org/10.1080/09540121.2013.793276.CrossRefGoogle Scholar
  27. Reis, A., Lencastre, L., Guerra, M., & Remor, E. (2009). Adaptação portuguesa do “Cuestionario para la Evaluación de la adhesión al Tratamiento Antirretroviral—VIH”. Psicologia: Saúde & Doenças, 10(2), 175–191.Google Scholar
  28. Reis, A., Lencastre, L., Guerra, M., & Remor, E. (2010). Relação entre a sintomatologia Psicopatológica, adesão ao tratamento e qualidade de vida na infecção pelo HIV e Aids. Psicologia: Reflexão e Crítica, 23(3), 187–196.  https://doi.org/10.1590/s0102-79722010000300002.CrossRefGoogle Scholar
  29. Remor, E. (2002). Valoración de la adhesión al tratamiento antirretroviral en pacientes VIH+. Psicothema, 14(2), 262–267.Google Scholar
  30. Rzeszutek, M., & Gruszczynska, E. (2018). Consistency of health-related quality of life among people living with HIV: Latent state-trait analysis. Health and Quality of Life Outcomes.  https://doi.org/10.1186/s12955-018-0929-4.CrossRefGoogle Scholar
  31. Schroecksnadel, K., Sarcletti, M., Winkler, C., Mumelter, B., Weiss, G., Funchs, D., et al. (2008). Quality of life and immune activation in patients with HIV-infection. Brain, Behavior, and Immunity, 22, 881–889.CrossRefGoogle Scholar
  32. Skevington, S. M., Lofty, M., O’Connell, K. A., & WHOQOL Group. (2004). The World Health Organization’s WHOQOL-Bref quality of life assessment: Psychometric properties and results of the international field trial. A report from the WHOQOL Group. Quality of Life Research, 13(2), 299–310.CrossRefGoogle Scholar
  33. Spindler, H., Denollet, J., Kruse, J., & Pedersen, S. S. (2009). Positive affect and negative affect correlate differently with distress and health-related quality of life in patients with cardiac conditions: Validation of the Danish Global Mood Scale. Journal of Psychosomatic Research, 67, 57–65.CrossRefGoogle Scholar
  34. Stauber, S., Schmid, J., Saner, H., Znoj, H., Saner, G., Grolimund, J., et al. (2013). Health-related quality of life is associated with positive affect in patients with coronary heart disease entering cardiac rehabilitation. Journal of Clinical Psychology in Medical Settings, 20, 79–87.  https://doi.org/10.1007/s10880-012-9311-6.CrossRefGoogle Scholar
  35. UNAIDS. (2019). Global AIDS monitoring 2019: Indicators for monitoring the 2016 political declaration on ending AIDS. Retrieved from http://aidsinfo.unaids.org/.
  36. Vaz Serra, A., Canavarro, M. C., Simões, M., Pereira, M., Gameiro, S., Quartilho, M. J., et al. (2006). Estudos psicométricos do instrumento de avaliação da qualidade de vida da Organização Mundial de Saúde (WHOQOL-Bref) para português de Portugal. Psiquiatria Clínica, 27(1), 41–49.Google Scholar
  37. WHOQOL Group. (1998). Development of the World Health Organization WHOQOL-BREF quality of life assessment. The WHOQOL group. Psychological Medicine, 28(3), 551–558.CrossRefGoogle Scholar

Copyright information

© Springer Nature B.V. 2019

Authors and Affiliations

  1. 1.Escola Superior de Saúde de Santa MariaPortoPortugal
  2. 2.Faculdade de Psicologia e de Ciências da Educação da Universidade do PortoPortoPortugal
  3. 3.Centre for Psychology of University of PortoPortoPortugal

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