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South Asian Cardiovascular Disease & Cancer Risk: Genetics & Pathophysiology

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Abstract

South Asians (SAs) are at heightened risk for cardiovascular disease as compared to other ethnic groups, facing premature and more severe coronary artery disease, and decreased insulin sensitivity. This disease burden can only be partially explained by conventional risk factors, suggesting the need for a specific cardiovascular risk profile for SAs. Current research, as explored through a comprehensive literature review, suggests the existence of population specific genetic risk factors such as lipoprotein(a), as well as population specific gene modulating factors. This review catalogues the available research on cardiovascular disease and genetics, anthropometry, and pathophysiology, and cancer genetics among SAs, with a geographical focus on the U.S. A tailored risk profile will hinge upon population customized classification and treatment guidelines, informed by continued research.

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Fig. 1

(Reproduced with permission from Enas et al. [55])

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Acknowledgements

This study was funded by National Institute on Minority Health and Health Disparities (R13 MD007147-01A1), National Cancer Institute (U54CA137788), National Cancer Institute (P30 CA008748). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. SAHI staff would like to thank the Steering Committee members, all working group co-chairs, the Memorial Sloan Kettering Cancer Center Library, Rohini Rau-Murthy and the SAHI interns for their assistance in assembling this document.

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Authors and Affiliations

  1. Stanford University School of Medicine, Palo Alto, CA, USA

    Latha Palaniappan

  2. Laboratory Medicine and Pathology, Fraser Health Authority, New Westminster, BC, Canada

    Arun Garg

  3. Coronary Artery Disease among Asian Indians (CADI) Research Foundation, Lisle, IL, USA

    Enas Enas

  4. Rollins School of Public Health, Global Epidemiology, Emory University, Atlanta, GA, USA

    Henrietta Lewis

  5. Columbia University, New York, NY, USA

    Sehrish Bari

  6. Division of Cardiology, University of Arizona College of Medicine, Phoenix, AZ, USA

    Martha Gulati

  7. The Warren Alpert Medical School, The Brown Human Rights Asylum Clinic (BHRAC), Brown University, Providence, RI, USA

    Cristina Flores

  8. South Asian Heart Center, El Camino Hospital, Mountain View, CA, USA

    Ashish Mathur & Cesar Molina

  9. The Mount Sinai Hospital, New York, NY, USA

    Jagat Narula

  10. I-Say, Bangladeshi American Youth Association, Teach & Travel, New York, NY, USA

    Shahid Rahman

  11. Immigrant Health and Cancer Disparities Center, Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, USA

    Jennifer Leng & Francesca Gany

  12. Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA

    Jennifer Leng & Francesca Gany

  13. Department of Healthcare Policy and Research, Weill Cornell Medical College, New York, NY, USA

    Jennifer Leng & Francesca Gany

  14. Department of Medicine, Weill Cornell Medical College, New York, NY, USA

    Francesca Gany

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  1. Latha Palaniappan
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Correspondence to Francesca Gany.

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Palaniappan, L., Garg, A., Enas, E. et al. South Asian Cardiovascular Disease & Cancer Risk: Genetics & Pathophysiology. J Community Health 43, 1100–1114 (2018). https://doi.org/10.1007/s10900-018-0527-8

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