Journal of Genetic Counseling

, Volume 26, Issue 3, pp 387–434 | Cite as

A Comprehensive Review of Pediatric Tumors and Associated Cancer Predisposition Syndromes

  • Sarah Scollon
  • Amanda Knoth Anglin
  • Martha Thomas
  • Joyce T. Turner
  • Kami Wolfe Schneider
Review Paper

Abstract

An understanding of the role of inherited cancer predisposition syndromes in pediatric tumor diagnoses continues to develop as more information is learned through the application of genomic technology. Identifying patients and their relatives at an increased risk for developing cancer is an important step in the care of this patient population. The purpose of this review is to highlight various tumor types that arise in the pediatric population and the cancer predisposition syndromes associated with those tumors. The review serves as a guide for recognizing genes and conditions to consider when a pediatric cancer referral presents to the genetics clinic.

Keywords

Pediatric cancer predisposition Genetics Genetic testing Tumors Cancer 

Notes

Conflicts of Interest

Ms. Knoth is a salaried employee of Myriad Genetic Laboratories, Inc. and holds MYGN stock. There are no additional conflicts of interest.

Contributorship

All co-authors have been listed in alphabetical order.

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Copyright information

© National Society of Genetic Counselors, Inc. 2017

Authors and Affiliations

  1. 1.Department of Pediatrics, Baylor College of Medicine, Texas Children’s Cancer CenterTexas Children’s HospitalHoustonUSA
  2. 2.Myriad Genetic LaboratoriesDaytonUSA
  3. 3.University of VirginiaCharlottesvilleUSA
  4. 4.Department of Genetics and MetabolismChildren’s National Medical CenterWashingtonUSA
  5. 5.Department of Pediatrics, University of Colorado, Center for Cancer and Blood DisordersChildren’s Hospital ColoradoAuroraUSA

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