Journal of Genetic Counseling

, Volume 24, Issue 1, pp 117–121 | Cite as

Parental Decisions Following Prenatal Diagnosis of Chromosomal Abnormalities: Implications for Genetic Counseling Practice in Japan

  • Nobuhiro SuzumoriEmail author
  • Kyoko Kumagai
  • Shinobu Goto
  • Akira Nakamura
  • Mayumi Sugiura-Ogasawara
Original Research


Parental decision-making to terminate or continue a pregnancy was studied after prenatal diagnosis of a chromosome aneuploidy among a sample of patients around the city of Nagoya, Japan. A total of 1,051 amniocentesis cases at 15–18 weeks of gestation were analyzed. Of these, 60 cases of chromosomal anomalies with aneuploidies were diagnosed by conventional cytogenetic analysis. Of the 45 diagnoses of autosomal chromosome aneuploidies, pregnancy was terminated in 93.3 % of the cases. Of the 15 cases diagnosed with sex chromosome aneuploidy, pregnancy was terminated in 46.7 %. Differences in parental decisions with respect to maternal age, gestational week at diagnosis, number of pregnancies per individual and existing number of children were not significant in patients diagnosed either with autosomal or sex chromosome aneuploidy. The findings indicate that when diagnosed with a chromosome aneuploidy in which a severe prognosis was expected, most couples decided to terminate the pregnancy in Japan. Implications of these findings for expanding the profession of genetic counseling are discussed and research recommendations are provided.


Prenatal diagnosis Termination Genetic counseling Chromosome aneuploidy Japan 


Conflict of Interest

Nobuhiro Suzumori, Kyoko Kumagai, Shinobu Goto, Akira Nakamura and Mayumi Sugiura-Ogasawara declare that they have no conflict of interest.

Human Studies and Informed Consent

All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2000 (5). Informed consent was obtained from all patients for being included in the study.

Animal Studies

No animal studies were carried out by the authors for this article.

Supplementary material

10897_2014_9744_MOESM1_ESM.pdf (631 kb)
ESM 1 (PDF 630 kb)


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Copyright information

© National Society of Genetic Counselors, Inc. 2014

Authors and Affiliations

  • Nobuhiro Suzumori
    • 1
    Email author
  • Kyoko Kumagai
    • 1
  • Shinobu Goto
    • 1
  • Akira Nakamura
    • 2
  • Mayumi Sugiura-Ogasawara
    • 1
  1. 1.Division of Clinical and Molecular Genetics, Department of Obstetrics and GynecologyNagoya City University Graduate School of Medical SciencesNagoyaJapan
  2. 2.Chiba University of CommerceIchikawaJapan

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