Journal of Genetic Counseling

, Volume 14, Issue 3, pp 165–181 | Cite as

Genetic Evaluation and Counseling of Couples with Recurrent Miscarriage: Recommendations of the National Society of Genetic Counselors

  • Mercy Y. Laurino
  • Robin L. Bennett
  • Devki S. Saraiya
  • Lisa Baumeister
  • Debra Lochner Doyle
  • Kathleen Leppig
  • Barbara Pettersen
  • Robert Resta
  • Larry Shields
  • Stefanie Uhrich
  • Elizabeth A. Varga
  • Wendy H. Raskind
Professional Issues

Abstract

The objective of this document is to provide recommendations for genetic evaluation and counseling of couples with recurrent miscarriage (RM). The recommendations are the opinions of the multidisciplinary Inherited Pregnancy Loss Working Group (IPLWG), with expertise in genetic counseling, medical genetics, maternal fetal medicine, internal medicine, infectious disease, cytogenetics, and coagulation disorders. The IPLWG defines RM as three or more clinically recognized consecutive or non-consecutive pregnancy losses occurring prior to fetal viability (<24 weeks gestation). These recommendations are provided to assist genetic counselors and other health care providers in clinical decision-making, as well as to promote consistency of patient care, guide the allocation of medical resources, and increase awareness of the psychosocial and cultural issues experienced by couples with RM. The IPLWG was convened with support from the March of Dimes Western Washington State Chapter and the University of Washington Division of Medical Genetics. The recommendations are U.S. Preventive Task Force Class III, and are based on clinical experiences, review of pertinent English-language published articles, and reports of expert committees. This document reviews the suspected causes of RM, provides indications for genetic evaluation and testing, addresses psychosocial and cultural considerations, and provides professional and patient resources. These recommendations should not be construed as dictating an exclusive course of medical management, nor does the use of such recommendations guarantee a particular outcome. The professional judgment of a health care provider, familiar with the circumstances of a specific case, should always supersede these recommendations.

Key Words

pregnancy loss recurrent miscarriage genetic counseling genetic testing National Society of Genetic Counselors practice guidelines 

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Copyright information

© Springer Science + Business Media, Inc. 2005

Authors and Affiliations

  • Mercy Y. Laurino
    • 1
  • Robin L. Bennett
    • 1
    • 11
  • Devki S. Saraiya
    • 1
  • Lisa Baumeister
    • 2
  • Debra Lochner Doyle
    • 3
  • Kathleen Leppig
    • 4
  • Barbara Pettersen
    • 5
  • Robert Resta
    • 6
  • Larry Shields
    • 7
  • Stefanie Uhrich
    • 8
  • Elizabeth A. Varga
    • 9
  • Wendy H. Raskind
    • 1
    • 10
  1. 1.Department of Medicine, Division of Medical GeneticsUniversity of WashingtonSeattle
  2. 2.Group Health CooperativeBurien Medical CenterSeattle
  3. 3.Washington State Department of HealthGenetic Services SectionKent
  4. 4.Department of Pathology, Group Health CooperativeGenetic Services and University of WashingtonSeattle
  5. 5.National Society of Genetic CounselorsGenetic Services CommitteeBend
  6. 6.Swedish Medical CenterPerinatal MedicineSeattle
  7. 7.Department of Obstetrics and Gynecology, School of MedicineUniversity of WashingtonSeattle
  8. 8.Prenatal Genetics and Fetal TherapyUniversity of WashingtonSeattle
  9. 9.Division of Human GeneticsOhio State UniversityColumbus
  10. 10.Department of Psychiatry and Behavioral SciencesUniversity of WashingtonSeattle
  11. 11.Division of Medical GeneticsUniversity of WashingtonSeattle

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