Surface Molecularly Imprinted Carbon Dots Based Core-Shell Material for Selective Fluorescence Sensing of Ketoprofen

  • Shikha Bhogal
  • Kuldeep Kaur
  • Seema Maheshwari
  • Ashok Kumar MalikEmail author


In this work, we report an environment friendly core-shell material based on Carbon Dot core and Molecularly Imprinted Polymer shell as sensor for highly selective fluorescence detection of ketoprofen. The Carbon Dots (CDs) were prepared by a hydrothermal method and the polymer layer around the CDs core was synthesised by sol-gel polymerisation. The prepared material was characterized by Fluorescence Spectroscopy, FT-IR Spectroscopy and Transmission Electron Spectroscopy (TEM). Fluorescence from the Carbon Dots- Molecularly Imprinted Polymer (CDs-MIP) was found to quench selectively in the presence of ketoprofen and quenching effect was found to be greater than for Non-Imprinted Polymer (CDs-NIP) which indicated the potential of CDs-MIP as a fluorescence sensing material for ketoprofen. The imprinting factor was obtained to be 2.35. Under optimized conditions, a linear response was obtained in the concentration range from 0.039 to 3.9 μM with a detection limit of 0.01 μM. The correlation coefficient was 0.999. The developed sensor was applied to determination of ketoprofen in human serum and urine samples with good recoveries ranging from 96 to 104% indicating successful application of the proposed sensor in biological fluids.


Carbon dots Molecularly imprinted polymer Ketoprofen Fluorescence determination 


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© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Shikha Bhogal
    • 1
  • Kuldeep Kaur
    • 2
  • Seema Maheshwari
    • 2
  • Ashok Kumar Malik
    • 1
    Email author
  1. 1.Department of ChemistryPunjabi University PatialaPatialaIndia
  2. 2.Department of ChemistryMata Gujri CollegeFatehgarh SahibIndia

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