Journal of Fluorescence

, Volume 22, Issue 2, pp 699–706 | Cite as

In vivo Monitoring of Organ-Selective Distribution of CdHgTe/SiO2 Nanoparticles in Mouse Model

  • Haiyan Chen
  • Sisi Cui
  • Zhenzhen Tu
  • Yueqing Gu
  • Xuemei Chi
Original Paper
First Online:
Received:
Accepted:

Abstract

CdHgTe/SiO2 nanoparticles were prepared by SiO2 capping on the surface of CdHgTe QDs. The characteristics, such as optical spectra, photostability, size and cell toxicity were investigated. The dynamic distribution of CdHgTe/SiO2 nanoparticles was in vivo monitored by near infrared fluorescence imaging system. CdHgTe/SiO2 nanoparticles acted as a novel fluorescence probe have a maximum fluorescence emission of 785 nm and high photo-stability. The hydrodynamic diameter of CdHgTe/SiO2 nanoparticles could be adjusted to 122.3 nm. Compared to CdHgTe QDs, inhibitory effects of CdHgTe/SiO2 nanoparticles on proliferation of HCT116 cells decreased to a certain extent. CdHgTe/SiO2 nanoparticles had their specific dynamic distribution behavior, which provided new perspectives for bio-distribution of nanoparticles.

Keywords

CdHgTe/SiO2 Nanoparticles Organ selective Bio-distribution Near infrared 
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Notes

Acknowledgement

The authors are grateful to Natural Science Foundation Committee of China (NSFC 81000666, NSFC30700779, NSFC30800257, NSFC31050110123 and NSFC81071194), China Pharmaceutical University (JKQ2009004), the Ministry of Science and Technology (2009ZX09310-004) for their financial supports.

References

  1. 1.
    Tisdale WA, Zhu XY (2011) Surface chemistry special feature: artificial atoms on semiconductor surfaces. Proc Natl Acad Sci U S A 108(3):965–970PubMedCrossRefGoogle Scholar
  2. 2.
    Wang C, Ma Q, Dou W, Kanwal S, Wang G, Yuan P, Su X (2009) Synthesis of aqueous CdTe quantum dots embedded silica nanoparticles and their applications as fluorescence probes. Talanta 77(4):1358–1364PubMedCrossRefGoogle Scholar
  3. 3.
    Boeneman K, Deschamps JR, Buckhout-White S, Prasuhn DE, Blanco-Canosa JB, Dawson PE, Stewart MH, Susumu K, Goldman ER, Ancona M, Medintz IL (2010) Quantum dot DNA bioconjugates: attachment chemistry strongly influences the resulting composite architecture. ACS Nano 4(12):7253–7266PubMedCrossRefGoogle Scholar
  4. 4.
    Fichter KM, Flajolet M, Greengard P, Vu TQ (2010) Kinetics of G-protein-coupled receptor endosomal trafficking pathways revealed by single quantum dots. Proc Natl Acad Sci U S A 107(43):18658–18663PubMedCrossRefGoogle Scholar
  5. 5.
    Maldiney T, Richard C, Seguin J, Wattier N, Bessodes M, Scherman D (2011) Effect of core diameter, surface coating, and PEG chain length on the biodistrib ution of persistent luminescence nanoparticles in mice. ACS Nano 5(2):854–862PubMedCrossRefGoogle Scholar
  6. 6.
    Chen H, Wang Y, Xu J, Ji J, Zhang J, Hu Y, Gu Y (2008) Non-invasive near infrared fluorescence imaging of CdHgTe quantum dots in mouse model. J Fluoresc 18(5):801–811PubMedCrossRefGoogle Scholar
  7. 7.
    Mahto SK, Park C, Yoon TH, Rhee SW (2010) Assessment of cytocompatibility of surface-modified CdSe/ZnSe quantum dots for BALB/3 T3 fibroblast cells. Toxicol In Vitro 24(4):1070–1077PubMedCrossRefGoogle Scholar
  8. 8.
    Wang L, Zhang J, Zheng Y, Yang J, Zhang Q, Zhu X (2010) Bioeffects of CdTe quantum dots on human umbilical vein endothelial cells. J Nanosci Nanotechnol 10:8591–8596PubMedCrossRefGoogle Scholar
  9. 9.
    Chithrani BD, Ghazani AA, Chan WC (2006) Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells. Nano Lett 6(4):662–668PubMedCrossRefGoogle Scholar
  10. 10.
    Fischer HC, Liu L, Pang KS, Chan WCW (2006) Pharmacokinetics of nanoscale quantum dots: in vivo distribution, sequestration, and clearance in the rat. Adv Funct Mater 16(10):1299–1305CrossRefGoogle Scholar
  11. 11.
    Buiculescu R, Hatzimarinaki M, Chaniotakis NA (2010) Biosilicated CdSe/ZnS quantum dots as photoluminescent transducers for acetylcholinesterase-based biosensors. Anal Bioanal Chem 398(7–8):3015–3021PubMedCrossRefGoogle Scholar
  12. 12.
    Cherkouk C, Rebohle L, Skorupa W (2011) Bioconjugation of the estrogen receptor hERα to a quantum dot dye for a controlled immobilization on a SiO2 surface. J Colloid Interface Sci 355(2):442–447PubMedCrossRefGoogle Scholar
  13. 13.
    Hu X, Gao X (2010) Silica-polymer dual layer-encapsulated quantum dots with remarkable stability. ACS Nano 4(10):6080–6086PubMedCrossRefGoogle Scholar
  14. 14.
    Darbandi M, Urban G, Krüger MA (2010) Facile synthesis method to silica coated CdSe/ZnS nanocomposites with tuneable size and optical properties. J Colloid Interface Sci 351(1):30–34PubMedCrossRefGoogle Scholar
  15. 15.
    Jie GF, Liu P, Zhang SS (2010) Highly enhanced electrochemiluminescence of novel gold/silica/CdSe-CdS nanostructures for ultrasensitive immunoassay of protein tumor marker. Chem, Commun (Camb) 46(8):1323–1325CrossRefGoogle Scholar
  16. 16.
    Ren T, Erker W, Basché T, Schärtl W (2010) Synthesis and spectroscopic properties of silica-dye-semiconductor nanocrystal hybrid particles. Langmuir 26(23):17981–17988PubMedCrossRefGoogle Scholar
  17. 17.
    Hu X, Zrazhevskiy P, Gao X (2009) Encapsulation of single quantum dots with mesoporous silica. Ann Biomed Eng 37(10):1960–1966PubMedCrossRefGoogle Scholar
  18. 18.
    Selvan ST, Tan TT, Ying JY (2005) Robust, non-cytotoxic, silica-coated cdse quantum dots with efficient photoluminescence. Adv Mater 17(13):1620–1625CrossRefGoogle Scholar
  19. 19.
    Pic E, Pons T, Bezdetnaya L, Leroux A, Guillemin F, Dubertret B, Marchal F (2010) Fluorescence imaging and whole-body biodistribution of near-infrared-emitting quantum dots after subcutaneous injection for regional lymph node mapping in mice. Mol Imaging Biol 12(4):394–405PubMedCrossRefGoogle Scholar
  20. 20.
    Dezhurov SV, Volkova IY, Wakstein MS (2011) FRET-based biosensor for oleic acid in nanomolar range with quantum dots as an energy donor. Bioconjug Chem 22(3):338–345PubMedCrossRefGoogle Scholar
  21. 21.
    Medintz IL, Mattoussi H, Clapp AR (2006) Potential clinical application of QDs. Int J Nanomed 3(2):151–167Google Scholar
  22. 22.
    Mancini MC, Kairdolf BA, Smith AM, Nie S (2008) Oxidative quenching and degradation of polymer-encapsulated quantum dots: new insights into the long-term fate and toxicity of nanocrystals in vivo. J Am Chem Soc 130(33):10836–10837PubMedCrossRefGoogle Scholar
  23. 23.
    Choi HS, Ipe BI, Misra P, Lee JH, Bawendi MG, Frangioni JV (2009) Tissue- and organ-selective biodistribution of NIR fluorescent quantum dots. Nano Lett 9(6):2354–2359PubMedCrossRefGoogle Scholar
  24. 24.
    De Jong WH, Hagens WI, Krystek P, Burger MC, Sips AJ, Geertsma RE (2008) Particle size-dependent organ distribution of gold nanoparticles after intravenous administration. Biomaterials 29(12):1912–1919PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Haiyan Chen
    • 1
  • Sisi Cui
    • 1
  • Zhenzhen Tu
    • 1
  • Yueqing Gu
    • 1
  • Xuemei Chi
    • 1
  1. 1.Department of Biomedical Engineering, School of Life Science and TechnologyChina Pharmaceutical UniversityNanjingChina

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