Journal of Fluorescence

, Volume 18, Issue 5, pp 801–811

Non-invasive Near Infrared Fluorescence Imaging of CdHgTe Quantum Dots in Mouse Model

  • Haiyan Chen
  • Yunqing Wang
  • Jing Xu
  • Jinzi Ji
  • Jian Zhang
  • Yuzhu Hu
  • Yueqing Gu
Original Paper

Abstract

Near infrared CdHgTe quantum dots (QDs) acted as biomarker for in vivo imaging were synthesized in aqueous solution. The size and the fluorescence wavelength of the synthesized quantum dots can be arbitrary manipulated by using different refluxing time. In particular, the fluorescence wavelength was extended to near infrared range (700∼900 nm), which make the in vivo imaging possible. Meanwhile, the characteristics, such as morphology, size, spectra, stability and toxicity were investigated. The dynamic bio-distribution, clearance from blood, liver and intestine in living animal were in vivo monitored by a NIR imaging system. The circulation of CdHgTe QDs in living mice was addressed semi-quantitatively according to the changes of fluorescence intensity. The high stability as well as high fluorescence intensity makes QDs particular interested candidates for in vivo imaging studies.

Keywords

Near infrared Quantum dots Stability In vivo Fluorescence imaging 

Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Haiyan Chen
    • 1
    • 2
  • Yunqing Wang
    • 2
  • Jing Xu
    • 3
  • Jinzi Ji
    • 3
  • Jian Zhang
    • 1
  • Yuzhu Hu
    • 2
  • Yueqing Gu
    • 1
  1. 1.Department of Biomedical Engineering, School of Life Science and TechnologyChina Pharmaceutical UniversityNanjingPeople’s Republic of China
  2. 2.Department of Analytical Chemistry, School of Basic ScienceChina Pharmaceutical UniversityNanjingPeople’s Republic of China
  3. 3.Department of Pharmacy, School of Pharmaceutical ScienceChina Pharmaceutical UniversityNanjingPeople’s Republic of China

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