Comparison of Three Health-Related Quality of Life Instruments to Evaluate Symptoms of Depression in HIV Patients in Brazil

  • Juliet Valdelamar-Jiménez
  • Liliane Lins-KustererEmail author
  • Suzane Tínel Gonzaga de Jesus
  • Eduardo Martins Netto
  • Carlos Brites


The evaluation of quality of life could be a useful indicator of depression in HIV patients. We compared the performance of three health-related quality of life (HRQoL) instruments for detecting depression. This nested case–control study included 200 HIV patients attended at an AIDS referral center. Depression was measured by Beck Depression Inventory (BDI). We accessed HRQoL by SF-36v2, HAT-QoL, and WHOQOL-HIV Bref. The depression diagnostic accuracy was evaluated by receiver operating characteristic (ROC) curve analysis. SF-36v2 presented negative correlation with BDI score (− 0.72 to − 0.40), and HAT-QoL (− 0.66 to 0.05) and WHOQoL-HIV Bref (− 0.67 to 0.32) domains presented negative and positive correlations. Mental Health (r = − .71) and Mental Component Summary (r = − .72) showed high negative correlation with BDI. SF-36v2 showed excellent measure by the ROC curve analysis in four factors, and high correlation in Mental Health and MCS. Sf-36 may represent a useful tool for screening of depressive symptoms in HIV patients.


Depression Mental health Health-related quality of life HIV/AIDS 



This research did not receive any specific grant from public or private funding agencies.

Compliance with Ethical Standards

Conflict of interest

Juliet Valdelamar-Jiménez, Liliane Lins-Kusterer, Suzane Tínel Gonzaga de Jesus, Eduardo Martins Netto, and Carlos Brites declare that they have no conflict of interests.

Ethical Approval

This study was in accordance with the ethical standards of the Brazilian national research (Resolution CNS 466/12 and with the Helsinki declaration and its later amendments. Informed consent was obtained from all individual participants included in the study.

Informed Consent

All individual participants who participated in the study signed a consent form.

Human and Animal Rights

The study was in accordance with the Declaration of Helsinki 2013 and the Brazilian National Health Council Resolution 499/12.


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© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.LAPI - Infectious Diseases Research LaboratoryEdgard Santos Federal University HospitalSalvadorBrazil
  2. 2.School of MedicineFederal University of BahiaSalvadorBrazil

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