A New Take on a Resource-Based Model of Quality of Life in Hemato-Oncological Patients: Demographic, Personal, and Social Factors
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This study tests a new comprehensive model accounting for the role of demographic, personal, and social factors in quality of life (QOL) among a sample of hematological cancer patients. We hypothesized that positive and negative affect would mediate the associations between these factors and QOL. Seventy-two patients were recruited at an outpatient hematological clinic in a midsized medical center in northern Israel. They completed measures of QOL, social support, positive and negative affect, and emotional intelligence (EI). Diagnostic and demographic information was retrieved from their files. Path analysis supported a model in which positive and negative affect mediated the association between income level, social support, EI, and QOL. This study presents a model accounting for QOL among hematological patients that for the first time pertains to demographic, personal, and interpersonal factors. This model may guide future research as well as future interventions to empower and support this fragile target population.
KeywordsHematological cancer Oncology Quality of life Emotional intelligence Resource model
This study was not supported by grant or funds and was conducted based on volunteer work of all involved researchers and assistants.
Compliance with Ethical Standards
Conflict of interest
Authors Leehu Zysberg, Sharon Hai, and Najib Dally declare that they have no conflicts of interest regarding this manuscript and its content.
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. All data for this study were collected and processed in accordance with the IRB rules and instructions of the Ziv Medical Center Ethics Committee, which reviewed the study plan and materials and approved them (IRB approval # 0080-14-ZIV).
Informed consent was obtained from all individual participants included in the study
- Baum, A., Herberman, H., & Cohen, L. (1995). Managing stress and managing illness: Survival and quality of life in chronic disease. Journal of clinical psychology in medical settings, 2(4), 309–333.Google Scholar
- Brady, M. J., Peterman, A. H., Fitchett, G., Mo, M., & Cella, D. (1999). A case for including spirituality in quality of life measurement in oncology. Psycho-Oncology, 8(5), 417–428. https://doi.org/10.1002/(SICI)1099-1611(199909/10)8:5%3C417::AID-PON398%3E3.0.CO;2-4.Google Scholar
- Cohen, S., & McKay, G. (1984). Social support, stress and the buffering hypothesis: A theoretical analysis. In A. Baum, S. E. Taylor & J. E. Singer (Eds.), Handbook of psychology and health (Vol. 4, pp. 253–267). Hillsdale: Lawrence Erlbaum.Google Scholar
- Cohen, S. R., Mount, B. M., Strobel, M. G., & Bui, F. (1995). The McGill quality of life questionnaire: A measure of quality of life appropriate for people with advanced disease. A preliminary study of validity and acceptability. Palliative Medicine, 9(3), 207–219. https://doi.org/10.1177/026921639500900306.Google Scholar
- Cohen, S. R., Mount, B. M., Tomas, J. J., & Mount, L. F. (1996). Existential well-being is an important determinant of quality of life: Evidence from the McGill quality of life questionnaire. Cancer: Interdisciplinary International Journal of the American Cancer Society, 77(3), 576–586.Google Scholar
- Dowdy, D. W., Eid, M. P., Sedrakyan, A., Mendez-Tellez, P. A., Pronovost, P. J., Herridge, M. S., & Needham, D. M. (2005). Quality of life in adult survivors of critical illness: A systematic review of the literature. Intensive Care Medicine, 31(5), 611–620. https://doi.org/10.1007/s00134-005-2592-6.Google Scholar
- Efficace, F., Baccarani, M., Breccia, M., Cottone, F., Alimena, G., Deliliers, G. L., … Mandelli, F. (2013). Chronic fatigue is the most important factor limiting health-related quality of life of chronic myeloid leukemia patients treated with imatinib. Leukemia, 27(7), 1511–1519. https://doi.org/10.1038/leu.2013.51.Google Scholar
- Efficace, F., Baccarani, M., Rosti, G., Cottone, F., Castagnetti, F., Breccia, M., … Mandelli, F. (2012). Investigating factors associated with adherence behaviour in patients with chronic myeloid leukemia: An observational patient-centered outcome study. British Journal of Cancer, 107(6), 904–909. https://doi.org/10.1038/bjc.2012.348.Google Scholar
- Fayers, P. M., & Machin, D. (2013). Quality of life: The assessment, analysis and interpretation of patient-reported outcomes. New York: Wiley.Google Scholar
- Gallo, L. C., & Matthews, K. A. (1999). Do negative emotions mediate the association between socioeconomic status and health? Annals of the New York Academy of Sciences, 896(1), 226–245. https://doi.org/10.1111/j.1749-6632.1999.tb08118.x.Google Scholar
- Goldberg, N., Aburava, M., & Haklai, Z. (2015). The leading causes of death in Israel. Jerusalem: Ministry of Health.Google Scholar
- Gonzalez-Saenz de Tejada, M., Bilbao, A., Bare, M., Briones, E., Sarasqueta, C., Quintana, J. M., … Caress-CCR Group. (2017). Association between social support, functional status, and change in health-related quality of life and changes in anxiety and depression in colorectal cancer patients. Psycho-Oncology, 26(9), 1263–1269. https://doi.org/10.1002/pon.4303.Google Scholar
- Israel Bureau of Statistics. (2015). New cases of malignant conditions. IBS Annual Journal, 6, Table 13.Google Scholar
- Jia, C., & Zhang, J. (2012). Psychometric characteristics of Duke Social Support Index in young rural Chinese population. Death Studies, 36(9), 858–869.Google Scholar
- Kiss, T. L., Abdolell, M., Jamal, N., Minden, M. D., Lipton, J. H., & Messner, H. A. (2002). Long-term medical outcomes and quality-of-life assessment of patients with chronic myeloid leukemia followed at least 10 years after allogeneic bone marrow transplantation. Journal of Clinical Oncology, 20(9), 2334–2343. https://doi.org/10.1200/JCO.2002.06.077.Google Scholar
- Koopman, C., Angell, K., Turner-Cobb, J. M., Kreshka, M. A., Donnelly, P., McCoy, R., … Spiegel, D. (2001). Distress, coping, and social support among rural women recently diagnosed with primary breast cancer. The Breast Journal, 7(1), 25–33. https://doi.org/10.1046/j.1524-4741.2001.007001025.x.Google Scholar
- Kubey, R., & Csikszentmihalyi, M. (2013). Television and the quality of life: How viewing shapes everyday experience. New York: Routledge.Google Scholar
- Leukemia and Lymphoma Society. (2017). Leukemia. Retrieved from http://www.lls.org/leukemia.
- McNally, J. W. (2009). Quality of life. In D. S. Carr (Ed.), Encyclopedia of the life course and human development (Vol. 3, p. 317). Detroit: Macmillan Reference.Google Scholar
- Mytko, J. J., & Knight, S. J. (1999). Body, mind and spirit: Towards the integration of religiosity and spirituality in cancer quality of life research. Psycho-Oncology, 8(5), 439–450. https://doi.org/10.1002/(SICI)1099-1611(199909/10)8:5%3C439::AID-PON421%3E3.0.CO;2-L.Google Scholar
- National Institutes of Health, National Cancer Institute. (2017). Cancer stat facts: Leukemia. Retrieved from https://seer.cancer.gov/statfacts/html/leuks.html.
- Penson, D. F., Stoddard, M. L., Pasta, D. J., Lubeck, D. P., Flanders, S. C., & Litwin, M. S. (2001). The association between socioeconomic status, health insurance coverage, and quality of life in men with prostate cancer. Journal of Clinical Epidemiology, 54(4), 350–358. https://doi.org/10.1016/S0895-4356(00)00312-7.Google Scholar
- Shanafelt, T. D., Bowen, D., Venkat, C., Slager, S. L., Zent, C. S., Kay, N. E., … Call, T. G. (2007). Quality of life in chronic lymphocytic leukemia: An international survey of 1482 patients. British Journal of Haematology, 139(2), 255–264. https://doi.org/10.1111/j.1365-2141.2007.06791.x.Google Scholar
- Taylor, S. E. (2007). Social support. In H. S. Friedman & R. C. Silver (Eds.), Foundations of health psychology (pp. 145–171). Oxford: Oxford University Press.Google Scholar
- Thoits, P. A. (2010). Stress and health: Major findings and policy implications. Journal of Health and Social Behavior, 51(1_suppl), S41–S53.Google Scholar
- Thornton, A. A., Perez, M. A., & Meyerowitz, B. E. (2004). Patient and partner quality of life and psychosocial adjustment following radical prostatectomy. Journal of Clinical Psychology in Medical Settings, 11(1), 15–30. https://doi.org/10.1023/B:JOCS.0000016266.06253.95.Google Scholar
- Tully, P. J., Baker, R. A., Turnbull, D. A., Winefield, H. R., & Knight, J. L. (2009). Negative emotions and quality of life six months after cardiac surgery: The dominant role of depression not anxiety symptoms. Journal of Behavioral Medicine, 32(6), 510. https://doi.org/10.1007/s10865-009-9225-4.Google Scholar
- Varni, J. W., Limbers, C. A., & Burwinkle, T. M. (2007). Impaired health-related quality of life in children and adolescents with chronic conditions: A comparative analysis of 10 disease clusters and 33 disease categories/severities utilizing the PedsQL™ 4.0 generic core scales. Health and Quality of Life Outcomes, 5, 43. https://doi.org/10.1186/1477-7525-5-43.Google Scholar
- Wang, X. S., Giralt, S. A., Mendoza, T. R., Engstrom, M. C., Johnson, B. A., … Cleeland, C. S. (2002). Clinical factors associated with cancer-related fatigue in patients being treated for leukemia and non-Hodgkin’s lymphoma. Journal of Clinical Oncology, 20(5), 1319–1328. https://doi.org/10.1200/JCO.2002.20.5.1319.Google Scholar
- Waters, E. B., Wake, M. A., Hesketh, K. D., Ashley, D. M., & Smibert, E. (2003). Health-related quality of life of children with acute lymphoblastic leukaemia: Comparisons and correlations between parent and clinician reports. International Journal of Cancer, 103(4), 514–518. https://doi.org/10.1002/ijc.10815.Google Scholar
- Watson, D., & Clark, L. A. (1999). The PANAS-X: Manual for the Positive and Negative Affect Schedule—Expanded form. Iowa City: University of Iowa, Department of Psychological & Brain Sciences.Google Scholar
- Wills, T. A. (1991). Social support and interpersonal relationships. In M. S. Clark (Ed.), Review of personality and social psychology (Vol. 12, pp. 265–289). Thousand Oaks: Sage.Google Scholar
- Yamazaki, S., Sokejima, S., Mizoue, T., Eboshida, A., & Fukuhara, S. (2005). Health-related quality of life of mothers of children with leukemia in Japan. Quality of Life Research: An International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation, 14(4), 1079–1085. https://doi.org/10.1007/s11136-004-3288-z.Google Scholar
- Zysberg, L. (2017). Emotional intelligence and health outcomes: Toward an ecological model of well-being. Hauppauge: Nova Publishers.Google Scholar