Journal of Contemporary Psychotherapy

, Volume 39, Issue 2, pp 93–100

Just How Effective are Antidepressant Medications? Results of a Major New Study

  • John J. Boren
  • Allan M. Leventhal
  • H. Edmund Pigott
Original Paper

Abstract

The STAR*D (Sequenced Treatment Alternatives to Relieve Depression) project was the largest and most extensive trial of antidepressants ever conducted. The study used state of- the-art methods to treat real patients coming to a hospital or psychiatric clinic for relief from depression. Because the first antidepressant is often ineffective for most patients, a sequence of drug treatments targeting various brain neurochemicals was carefully planned. This article will review the complex treatments and the various outcomes, including the frequency of relapse during twelve months of follow-up care.

Keywords

Depression Treatment Antidepressants Relapse 

References

  1. Fava, M., Rush, A. J., Wisniewski, S. R., Nierenberg, A. A., et al. (2006). A comparison of mirtazapine and nortriptyline following two consecutive failed medication treatments for depressed outpatients: A STAR*D Report. The American Journal of Psychiatry, 163, 1161–1172.PubMedCrossRefGoogle Scholar
  2. Kirsch, I., Moore, T. J., Scobabria, A., & Nicholls, S. S. (2002). The emperor’s new drugs: An analysis of antidepressive medication data submitted to the U. S. food and drug administration. Prevention & Treatment, 5(23). http://content.apa.org/journals/pre/5/1/33.
  3. McGrath, P. J., Stewart, J. W., Fava, M., Trivedi, M. H., et al. (2006). Tranylcypromine versus venlafaxine plus mirtazapine following three failed antidepressant medication trials for depression: A STAR*D Report. The American Journal of Psychiatry, 163, 1531–1541.PubMedCrossRefGoogle Scholar
  4. Nierenberg, A. A., Fava, M., Trivedi, M. D., Wisniewski, S. R., et al. (2006). A comparison of lithium and T3 augmentation following two failed medication treatments for depression: A STAR*D report. The American Journal of Psychiatry, 163, 1519–1530.PubMedCrossRefGoogle Scholar
  5. Rush, A. J., Fava, M., Wisniewski, S. R., Lavori, P. W., et al. (2004). Sequenced treatment alternatives to relieve depression (STAR*D): Rationale and design. Controlled Clinical Trials, 25, 119–142.PubMedCrossRefGoogle Scholar
  6. Rush, A. J., Trivedi, M. H., Wisniewski, S. R., Nierenberg, A. A., et al. (2006a). Acute and longer-term outcomes in depressed outpatients requiring one or several treatment steps: A STAR*D report. The American Journal of Psychiatry, 163, 1905–1917.PubMedCrossRefGoogle Scholar
  7. Rush, A. J., Trivedi, M. H., Wisniewski, S. R., Stewart, J. W., et al. (2006b). Bupropion-sr, sertraline, or venlafaxine-xr after failure of SSRIs for depression. The New England Journal of Medicine, 354, 1231–1242.PubMedCrossRefGoogle Scholar
  8. Thase, M. E., Friedman, E. S., Biggs, M. M., Wisniewski, S. R., et al. (2007). Cognitive therapy versus medication in augmentation and switch strategies as second-step treatments: A STAR*D report. The American Journal of Psychiatry, 164, 739–752.PubMedCrossRefGoogle Scholar
  9. Trivedi, M. H., Fava, M., Wisniewski, S. R., Thase, M. E., et al. (2006a). Medication augmentation after the failure of SSRIs for depression. The New England Journal of Medicine, 354, 1243–1252.PubMedCrossRefGoogle Scholar
  10. Trivedi, M. H., Rush, A. J., Wisniewski, S. S., et al. (2006b). Evaluation of outcomes with citalopram for depression using measurement-based care in STAR*D: Implications for clinical practice. The American Journal of Psychiatry, 163, 28–40.PubMedCrossRefGoogle Scholar
  11. Turner, E. H., Matthews, A. M., et al. (2008). Selective publication of antidepressant trials and its influence on apparent efficacy. The New England Journal of Medicine, 358, 252–260.PubMedCrossRefGoogle Scholar
  12. Vedatam, S. (2006, March 23). Drugs cure depression in half of patients: Doctors have mixed reactions to study findings. The Washington Post, p. A1.Google Scholar

Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • John J. Boren
    • 1
  • Allan M. Leventhal
    • 2
  • H. Edmund Pigott
    • 3
  1. 1.Chapel HillUSA
  2. 2.Silver SpringUSA
  3. 3.ClarksvilleUSA

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