Pre-specified outcomes must be followed

  • Hans-Joachim PriebeEmail author
Letter to the Editor

To the Editor

The publication by Licker et al. [1] raises several considerable concerns. First, in the abstract the authors claim that this was a randomized controlled trial. This, however, is not the case. The article merely reports the findings of an a priori non-defined subset of patients in whom transesophageal echocardiographic (TEE) examination was of good quality following coronary artery bypass surgery with or without aortic valve replacement (AVR). These patients were part of a previously reported study by the same group of authors [2]. The unequal number of patients in each group (46 vs. 54) documents the lack of randomization.

Second, the authors claim that the reported investigation in this subset of patients was pre-planned as per trial registration [3]. This, again, is an incorrect statement. The respective trial registration lists as primary outcome measure 48 h postcardiotomy ventricular dysfunction (PCVD), and as secondary outcome measures intraoperative systolic and...


Compliance with ethical standards

Conflict of interest

The author does not have any conflict of interest.


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    Licker M, Reynaud T, Garofano N, et al. Pretreatment with glucose–insulin–potassium improves ventricular performances after coronary artery bypass surgery: a randomized controlled trial. J Clin Monit Comput. 2019. Scholar
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    Ellenberger C, Sologashvili T, Kreienbuhl L, Cikirikcioglu M, Diaper J, Licker M. Myocardial protection by glucose-insulin-potassium in moderate- to high-risk patients undergoing elective on-pump cardiac surgery: a randomized controlled trial. Anesth Analg. 2018;126:1133–41.CrossRefGoogle Scholar
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    Schulz KF, Altman DG, Moher D, CONSORT Group. CONSORT 2010 statement: updated guidelines for reporting parallel group randomized trials. BMJ. 2010;340:c332.CrossRefGoogle Scholar
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Copyright information

© Springer Nature B.V. 2019

Authors and Affiliations

  1. 1.Department of Anesthesiology and Critical CareMedical Center University of FreiburgFreiburgGermany

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