Trending algorithm discriminates hemodynamic from injury related TcMEP amplitude loss

  • Paul JasiukaitisEmail author
  • Russ Lyon
Original Research


Jasiukaitis and Lyon (J Clin Monit Comput,, 2018) described an motor evoked potential (MEP)amplitude trending system to detect MEP amplitude loss against a background of MEP variability. They found that the end of case value of a running R2 triggered by a set MEP amplitude loss criterion appeared to discriminate new injury from non-injury in a small sample of three patients. The present study examines the predictive capability of the running R2 in a larger sample of patients (21 injured and 19 non-injured). It also varies the amplitude loss criterion (50%, 65% and 80%) for triggering the running R2 and the numbers of points used in the moving linear regression (8, 12 and 16). 40 patients who had undergone correction for lumbar deformity were retrospectively examined. 21 of these woke up with a newly acquired radicular injury, 19 did not but were characterized by hypovolemic hemorrhage. All 40 patients had sufficient MEP amplitude loss sometime during their procedure to cause the monitoring specialist to report this to the surgeon and anesthesia. End-of-case running R2s were significantly larger in the injury group. Using an 80% amplitude loss criterion to trigger the running R2 proved to be too stringent, causing reduced sensitivity. The running R2 appeared to have equivalent sensitivity to that of conventional MEP amplitude loss ratios, but superior specificity within this monitoring challenged sample. The different number of points for the moving regressions did not have any significant effect. End-of-case R2 values greater than 60% appeared to be highly predictive of new post-operative deficit, while values less than 40% appeared to insure no new deficit. The proposed trending system can discriminate injury from non-injury outcomes when compressive radicular injury during correction for lumbar deformity is involved. This discrimination appears to be successful even when MEP amplitude loss for non-iatrogenic reasons (i.e., hemorrhage) is also occurring.


Intraoperative motor evoked potential changes Successful discrimination Hemodynamic stress from radicular injury 


Compliance with ethical standards

Conflict of interest

The authors have no conflict of interest with regards to this study.

Ethical approval

The data reported are retrospective data. Patient treatment was not altered or affected in any way by gathering this data. No patient or medical provider identities are revealed in the submitted article.


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Copyright information

© Springer Nature B.V. 2019

Authors and Affiliations

  1. 1.CNIMSan FranciscoUSA
  2. 2.DABNM, Division of Operating RoomsUniversity of California San FranciscoSan FranciscoUSA

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