Journal of Clinical Monitoring and Computing

, Volume 31, Issue 6, pp 1123–1132 | Cite as

Cerebral hemodynamics in sepsis assessed by transcranial Doppler: a systematic review and meta-analysis

  • Daniel Silva de Azevedo
  • Angela Salomao Macedo Salinet
  • Marcelo de Lima Oliveira
  • Manoel Jacobsen Teixeira
  • Edson Bor-Seng-Shu
  • Ricardo de Carvalho Nogueira
Review Paper


Cerebral microcirculation is gradually compromised during sepsis, with significant reductions in the function of capillaries and blood perfusion in small vessels. Transcranial Doppler ultrasound (TCD) has been used to assess cerebral circulation in a typical clinical setting. This study was to systematically review TCD studies, assess their methodological quality, and identify trends that can be associated with the temporal evolution of sepsis and its clinical outcome. A meta-analysis of systematic reviews was conducted according to the PRISMA statement. Articles were searched from 1982 until the conclusion of this review in December 2015. Twelve prospective and observational studies were selected. Evaluations of cerebral blood flow, cerebral autoregulation, and carbon dioxide (CO2) vasoreactivity were summarized. A temporal pattern of the evolution of the illness was found. In early sepsis, the median blood flow velocity (Vm) and pulsatility index (PI) increased, and the cerebral autoregulation (CA) remained unchanged. In contrast, Vm normalization, PI reduction and CA impairment were found in later sepsis (patients with severe sepsis or septic shock). Cerebral haemodynamic is impaired in sepsis. Modifications in cerebral blood flow may be consequence to the endothelial dysfunction of the microvasculature induced by the release of inflammatory mediators. A better understanding of cerebral hemodynamics may improve the clinical management of patients with sepsis and, consequently, improve clinical outcomes.


Transcranial Doppler in sepsis Cerebral hemodinamycs in sespsis Cerebral autoregulation in sepsis 


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Copyright information

© Springer Science+Business Media Dordrecht 2016

Authors and Affiliations

  • Daniel Silva de Azevedo
    • 1
  • Angela Salomao Macedo Salinet
    • 1
  • Marcelo de Lima Oliveira
    • 1
  • Manoel Jacobsen Teixeira
    • 1
  • Edson Bor-Seng-Shu
    • 1
  • Ricardo de Carvalho Nogueira
    • 1
  1. 1.Neurology Department, School of Medicine, Hospital das ClinicasUniversity of São PauloSão PauloBrazil

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