Journal of Clinical Monitoring and Computing

, Volume 30, Issue 5, pp 511–518 | Cite as

The effects of advanced monitoring on hemodynamic management in critically ill patients: a pre and post questionnaire study

  • Azriel Perel
  • Bernd SaugelEmail author
  • Jean-Louis Teboul
  • Manu L. N. G. Malbrain
  • Francisco Javier Belda
  • Enrique Fernández-Mondéjar
  • Mikhail Kirov
  • Julia Wendon
  • Roger Lussmann
  • Marco Maggiorini
Original Research


In critically ill patients, many decisions depend on accurate assessment of the hemodynamic status. We evaluated the accuracy of physicians’ conventional hemodynamic assessment and the impact that additional advanced monitoring had on therapeutic decisions. Physicians from seven European countries filled in a questionnaire in patients in whom advanced hemodynamic monitoring using transpulmonary thermodilution (PiCCO system; Pulsion Medical Systems SE, Feldkirchen, Germany) was going to be initialized as part of routine care. The collected information included the currently proposed therapeutic intervention(s) and a prediction of the expected transpulmonary thermodilution-derived variables. After transpulmonary thermodilution measurements, physicians recorded any changes that were eventually made in the original therapeutic plan. A total of 315 questionnaires pertaining to 206 patients were completed. The mean difference (±standard deviation; 95 % limits of agreement) between estimated and measured hemodynamic variables was −1.54 (±2.16; −5.77 to 2.69) L/min for the cardiac output (CO), −74 (±235; −536 to 387) mL/m2 for the global end-diastolic volume index (GEDVI), and −0.5 (±5.2; −10.6 to 9.7) mL/kg for the extravascular lung water index (EVLWI). The percentage error for the CO, GEDVI, and EVLWI was 66, 64, and 95 %, respectively. In 54 % of cases physicians underestimated the actual CO by more than 20 %. The information provided by the additional advanced monitoring led 33, 22, 22, and 13 % of physicians to change their decisions about fluids, inotropes, vasoconstrictors, and diuretics, respectively. The limited clinical ability of physicians to correctly assess the hemodynamic status, and the significant impact that more physiological information has on major therapeutic decisions, support the use of advanced hemodynamic monitoring in critically ill patients.


Hemodynamic monitoring Decision making Transpulmonary thermodilution Cardiac output Global end-diastolic volume Extravascular lung water 



We thankfully acknowledge the contribution of the staff of the participating ICUs, and in particular the contribution of the following physicians in data collection: G. Kourakin and S. Preisman, Sheba Medical Center, Tel Aviv University, Israel; H. Dits, K. Schoonheydt, N. Van Regenmortel, and I. De laet, Ziekenhuis Netwerk Antwerpen, Campus ZNA Stuivenberg, Antwerp, Belgium; A. Aguilar, Hospital Clinico Universitario, Valencia, Spain; A. Smetkin, Northern State Medical University, Arkhangelsk, Russian Federation; C. Karvellas, King’s College Hospital, London, UK; A. Haller, Kantonsspital Winterthur, and M. Lang, Spital Frauenfeld, Switzerland.

Conflict of interests

AP, BS, JLT, MLNGM, JB, EF-M, MK, JW, and MM are members of the Medical Advisory Board of Pulsion Medical Systems SE (Feldkirchen, Germany) and received honoraria and refunds of travel expenses from Pulsion Medical Systems SE (Feldkirchen, Germany). However, the study was not sponsored nor funded by this company or any other external source. RL has no potential conflicts of interest to declare.


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Copyright information

© Springer Science+Business Media Dordrecht 2015

Authors and Affiliations

  • Azriel Perel
    • 1
  • Bernd Saugel
    • 2
    Email author
  • Jean-Louis Teboul
    • 3
    • 4
  • Manu L. N. G. Malbrain
    • 5
  • Francisco Javier Belda
    • 6
  • Enrique Fernández-Mondéjar
    • 7
  • Mikhail Kirov
    • 8
  • Julia Wendon
    • 9
  • Roger Lussmann
    • 10
    • 11
  • Marco Maggiorini
    • 12
  1. 1.Department of Anesthesiology and Critical Care, Sheba Medical CenterTel Aviv UniversityTel AvivIsrael
  2. 2.Department of Anesthesiology, Center of Anesthesiology and Intensive Care MedicineUniversity Medical Center Hamburg-EppendorfHamburgGermany
  3. 3.Paris-Sud Medical SchoolParis-Saclay UniversityLe Kremlin-BicêtreFrance
  4. 4.Paris-Saclay UniversityLe Kremlin-BicêtreFrance
  5. 5.Department of Intensive CareZiekenhuis Netwerk AntwerpenAntwerpBelgium
  6. 6.Department of Anaesthesia and Surgical Critical CareHospital Clinico UniversitarioValenciaSpain
  7. 7.Neuro-Trauma Intensive Care UnitUniversity Hospital Virgen de LAS NievesGranadaSpain
  8. 8.Department of Anaesthesiology and Intensive Care MedicineNorthern State Medical UniversityArkhangelskRussia
  9. 9.Liver Intensive CareKing’s College HospitalLondonUK
  10. 10.Surgical Intensive Care MedicineKantonsspital St. GallenSt. GallenSwitzerland
  11. 11.Intensive Care Unit of the Institute of Anesthesiology and Intensive Care MedicineKlinik HirslandenZurichSwitzerland
  12. 12.Medical Intensive Care Unit of the Department of Internal MedicineUniversity Hospital ZurichZurichSwitzerland

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