Journal of Clinical Monitoring and Computing

, Volume 30, Issue 1, pp 87–99 | Cite as

Impact of early haemodynamic goal-directed therapy in patients undergoing emergency surgery: an open prospective, randomised trial

  • Gordana Pavlovic
  • John Diaper
  • Christoph Ellenberger
  • Angela Frei
  • Karim Bendjelid
  • Fanny Bonhomme
  • Marc LickerEmail author
Original Research


Haemodynamic goal-directed therapies (GDT) may improve outcome following elective major surgery. So far, few data exist regarding haemodynamic optimization during emergency surgery. In this randomized, controlled trial, 50 surgical patients with hypovolemic or septic conditions were enrolled and we compared two algorithms of GDTs based either on conventional parameters and pressure pulse variation (control group) or on cardiac index, global end-diastolic volume index and stroke volume variation as derived from the PiCCO monitoring system (optimized group). Postoperative outcome was estimated by a composite index including major complications and by the Sequential Organ Failure Assessment (SOFA) Score within the first 3 days after surgery (POD1, POD2 and POD3). Data from 43 patients were analyzed (control group, N = 23; optimized group, N = 20). Similar amounts of fluid were given in the two groups. Intraoperatively, dobutamine was given in 45 % optimized patients but in no control patients. Major complications occurred more frequently in the optimized group [19 (95 %) versus 10 (40 %) in the control group, P < 0.001]. Likewise, SOFA scores were higher in the optimized group on POD1 (10.2 ± 2.5 versus 6.6 ± 2.2 in the control group, P = 0.001), POD2 (8.4 ± 2.6 vs 5.0 ± 2.4 in the control group, P = 0.002) and POD 3 (5.2 ± 3.6 and 2.2 ± 1.3 in the control group, P = 0.01). There was no significant difference in hospital mortality (13 % in the control group and 25 % in the optimized group). Haemodynamic optimization based on volumetric and flow PiCCO-derived parameters was associated with a less favorable postoperative outcome compared with a conventional GDT protocol during emergency surgery.


Haemodynamic monitoring Postoperative complications Emergency surgery Cardiac output Inotropes 


Conflict of interest



  1. 1.
    Angus DC, van der Poll T. Severe sepsis and septic shock. N Engl J Med. 2013;369:840–51.CrossRefPubMedGoogle Scholar
  2. 2.
    Lenz A, Franklin GA, Cheadle WG. Systemic inflammation after trauma. Injury. 2007;38:1336–45.CrossRefPubMedGoogle Scholar
  3. 3.
    Dellinger RP, Levy MM, Rhodes A, Annane D, Gerlach H, Opal SM, Sevransky JE, Sprung CL, Douglas IS, Jaeschke R, et al. Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock, 2012. Intensiv Care Med. 2013;39:165–228.CrossRefGoogle Scholar
  4. 4.
    Wenzel V, Russo S, Arntz HR, Bahr J, Baubin MA, Bottiger BW, Dirks B, Dorges V, Eich C, Fischer M et al. Anaesthesist. 2006, 55:958–966, 968–972.Google Scholar
  5. 5.
    Rady MY, Rivers EP, Nowak RM. Resuscitation of the critically ill in the ED: responses of blood pressure, heart rate, shock index, central venous oxygen saturation, and lactate. Am J Emerg Med. 1996;14:218–25.CrossRefPubMedGoogle Scholar
  6. 6.
    Ekbal NJ, Dyson A, Black C, Singer M. Monitoring tissue perfusion, oxygenation, and metabolism in critically ill patients. Chest. 2013;143:1799–808.CrossRefPubMedGoogle Scholar
  7. 7.
    Fouche Y, Sikorski R, Dutton RP. Changing paradigms in surgical resuscitation. Crit Care Med. 2010;38(Suppl):S411–20.CrossRefPubMedGoogle Scholar
  8. 8.
    Shoemaker WC, Montgomery ES, Kaplan E, Elwyn DH. Physiologic patterns in surviving and nonsurviving shock patients. Use of sequential cardiorespiratory variables in defining criteria for therapeutic goals and early warning of death. Arch Surg. 1973;106:630–6.CrossRefPubMedGoogle Scholar
  9. 9.
    Shoemaker WC, Mohr PA, Printen KJ, Brown RS, Amato JJ, Carey JS, Youssef S, Reinhard JM, Kim SI, Kark AE. Use of sequential physiologic measurements for evaluation and therapy of uncomplicated septic shock. Surg Gynecol Obst. 1970;131:245–54.Google Scholar
  10. 10.
    Tuchschmidt J, Fried J, Astiz M, Rackow E. Elevation of cardiac output and oxygen delivery improves outcome in septic shock. Chest. 1992;102:216–20.CrossRefPubMedGoogle Scholar
  11. 11.
    Rivers E, Nguyen B, Havstad S, Ressler J, Muzzin A, Knoblich B, Peterson E, Tomlanovich M. Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med. 2001;34:1368–77.CrossRefGoogle Scholar
  12. 12.
    Preisman S, Pfeiffer U, Lieberman N, Perel A. New monitors of intravascular volume: a comparison of arterial pressure waveform analysis and the intrathoracic blood volume. Intensiv Care Med. 1997;23:651–7.CrossRefGoogle Scholar
  13. 13.
    Shapiro NI, Howell MD, Talmor D, Nathanson LA, Lisbon A, Wolfe RE, Weiss JW. Serum lactate as a predictor of mortality in emergency department patients with infection. Ann Emerg Med. 2005;45:524–8.CrossRefPubMedGoogle Scholar
  14. 14.
    Lopes MR, Oliveira MA, Pereira VO, Lemos IP, Auler JO Jr, Michard F. Goal-directed fluid management based on pulse pressure variation monitoring during high-risk surgery: a pilot randomized controlled trial. Crit Care. 2007;11:R100.PubMedCentralCrossRefPubMedGoogle Scholar
  15. 15.
    Lobo SM, de Oliveira NE. Clinical review: what are the best hemodynamic targets for noncardiac surgical patients? Crit Care. 2013;17:210.PubMedCentralCrossRefPubMedGoogle Scholar
  16. 16.
    Antonelli M, Levy M, Andrews PJ, Chastre J, Hudson LD, Manthous C, Meduri GU, Moreno RP, Putensen C, Stewart T, et al. Hemodynamic monitoring in shock and implications for management. International consensus conference, Paris, France, 27–28 April 2006. Intensiv Care Med. 2007;33:575–90.CrossRefGoogle Scholar
  17. 17.
    Pearse R, Dawson D, Fawcett J, Rhodes A, Grounds RM, Bennett ED. Early goal-directed therapy after major surgery reduces complications and duration of hospital stay. A randomised, controlled trial [ISRCTN38797445]. Crit Care. 2005;9:R687–93.PubMedCentralCrossRefPubMedGoogle Scholar
  18. 18.
    Pearse RM, Harrison DA, MacDonald N, Gillies MA, Blunt M, Ackland G, Grocott MP, Ahern A, Griggs K, Scott R, et al. Effect of a perioperative, cardiac output-guided hemodynamic therapy algorithm on outcomes following major gastrointestinal surgery: a randomized clinical trial and systematic review. JAMA. 2014;311:2181–90.CrossRefPubMedGoogle Scholar
  19. 19.
    Kern JW, Shoemaker WC. Meta-analysis of hemodynamic optimization in high-risk patients. Crit Care Med. 2002;30:1686–92.CrossRefPubMedGoogle Scholar
  20. 20.
    Arulkumaran N, Corredor C, Hamilton MA, Ball J, Grounds RM, Rhodes A, Cecconi M. Cardiac complications associated with goal-directed therapy in high-risk surgical patients: a meta-analysis. Br J Anaesth. 2014;112:648–59.CrossRefPubMedGoogle Scholar
  21. 21.
    Cecconi M, Corredor C, Arulkumaran N, Abuella G, Ball J, Grounds RM, Hamilton M, Rhodes A. Clinical review: goal-directed therapy-what is the evidence in surgical patients? The effect on different risk groups. Crit Care. 2013;17:209.PubMedCentralCrossRefPubMedGoogle Scholar
  22. 22.
    Dunser MW, Ruokonen E, Pettila V, Ulmer H, Torgersen C, Schmittinger CA, Jakob S, Takala J. Association of arterial blood pressure and vasopressor load with septic shock mortality: a post hoc analysis of a multicenter trial. Crit Care. 2009;13:R181.PubMedCentralCrossRefPubMedGoogle Scholar
  23. 23.
    Hayes MA, Timmins AC, Yau EH, Palazzo M, Hinds CJ, Watson D. Elevation of systemic oxygen delivery in the treatment of critically ill patients. N Engl J Med. 1994;330:1717–22.CrossRefPubMedGoogle Scholar
  24. 24.
    Wilms H, Mittal A, Haydock MD, van den Heever M, Devaud M, Windsor JA. A systematic review of goal directed fluid therapy: rating of evidence for goals and monitoring methods. J Crit Care. 2014;29:204–9.CrossRefPubMedGoogle Scholar
  25. 25.
    Dellinger RP, Levy MM, Carlet JM, Bion J, Parker MM, Jaeschke R, Reinhart K, Angus DC, Brun-Buisson C, Beale R, et al. Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2008. Crit Care Med. 2008;36:296–327.CrossRefPubMedGoogle Scholar
  26. 26.
    Kobayashi L, Costantini TW, Coimbra R. Hypovolemic shock resuscitation. Surg Clin N Am. 2012;92:1403–23.CrossRefPubMedGoogle Scholar
  27. 27.
    Williams DJ, Walker JD. A nomogram to calculate the physiological and operative severity score for the enUmeration of Mortality and morbidity (POSSUM). Br J Surg. 2014;101:239–45.CrossRefPubMedGoogle Scholar
  28. 28.
    Dindo D, Demartines N, Clavien PA. Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg. 2004;240:205–13.PubMedCentralCrossRefPubMedGoogle Scholar
  29. 29.
    Fueglistaler P, Amsler F, Schuepp M, Fueglistaler-Montali I, Attenberger C, Pargger H, Jacob AL, Gross T. Prognostic value of sequential organ failure assessment and simplified acute physiology II score compared with trauma scores in the outcome of multiple-trauma patients. Am J Surg. 2010;200:204–14.CrossRefPubMedGoogle Scholar
  30. 30.
    Ochiai T, Hiranuma S, Takiguchi N, Ito K, Kawaguchi A, Iwai T, Arii S. SOFA score predicts postoperative outcome of patients with colorectal perforation. Hepatogastroenterology. 2004;51:1007–10.PubMedGoogle Scholar
  31. 31.
    Lees N, Hamilton M, Rhodes A. Clinical review: goal-directed therapy in high risk surgical patients. Crit Care. 2009;13(5):231.PubMedCentralCrossRefPubMedGoogle Scholar
  32. 32.
    Boland MR, Noorani A, Varty K, Coffey JC, Agha R, Walsh SR. Perioperative fluid restriction in major abdominal surgery: systematic review and meta-analysis of randomized, clinical trials. World J Surg. 2013;37:1193–202.CrossRefPubMedGoogle Scholar
  33. 33.
    Grocott MP, Dushianthan A, Hamilton MA, Mythen MG, Harrison D, Rowan K. Optimisation systematic review steering G: perioperative increase in global blood flow to explicit defined goals and outcomes after surgery: a cochrane systematic review. Br J Anaesth. 2013;111:535–48.CrossRefPubMedGoogle Scholar
  34. 34.
    Challand C, Struthers R, Sneyd JR, Erasmus PD, Mellor N, Hosie KB, Minto G. Randomized controlled trial of intraoperative goal-directed fluid therapy in aerobically fit and unfit patients having major colorectal surgery. Br J Anaesth. 2012;108:53–62.CrossRefPubMedGoogle Scholar
  35. 35.
    Ghneim MH, Regner JL, Jupiter DC, Kang F, Bonner GL, Bready MS, Frazee R, Ciceri D, Davis ML. Goal directed fluid resuscitation decreases time for lactate clearance and facilitates early fascial closure in damage control surgery. Am J Surg. 2013;206:995–9.CrossRefPubMedGoogle Scholar
  36. 36.
    Jansen TC, van Bommel J, Bakker J. Blood lactate monitoring in critically ill patients: a systematic health technology assessment. Crit Care Med. 2009;37(10):2827–39.CrossRefPubMedGoogle Scholar
  37. 37.
    Vincent JL, Ferreira F, Moreno R. Scoring systems for assessing organ dysfunction and survival. Crit Care Clin. 2000;16:353–66.CrossRefPubMedGoogle Scholar
  38. 38.
    Meyer ZC, Schreinemakers JM, Mulder PG, de Waal RA, Ermens AA, van der Laan L. The role of C-reactive protein and the SOFA score as parameter for clinical decision making in surgical patients during the intensive care unit course. PLoS One. 2013;8:e55964.PubMedCentralCrossRefPubMedGoogle Scholar
  39. 39.
    Hamilton MA, Cecconi M, Rhodes A. A systematic review and meta-analysis on the use of preemptive hemodynamic intervention to improve postoperative outcomes in moderate and high-risk surgical patients. Anesth Analg. 2011;112:1392–402.CrossRefPubMedGoogle Scholar
  40. 40.
    Harten J, Crozier JE, McCreath B, Hay A, McMillan DC, McArdle CS, Kinsella J. Effect of intraoperative fluid optimisation on renal function in patients undergoing emergency abdominal surgery: a randomised controlled pilot study (ISRCTN 11799696). Int J Surg. 2008;6:197–204.CrossRefPubMedGoogle Scholar
  41. 41.
    Licker M, Diaper J, Villiger Y, Spiliopoulos A, Licker V, Robert J, Tschopp JM. Impact of intraoperative lung-protective interventions in patients undergoing lung cancer surgery. Crit Care. 2009;13:R41.PubMedCentralCrossRefPubMedGoogle Scholar
  42. 42.
    Takala J, Ruokonen E, Tenhunen JJ, Parviainen I, Jakob SM. Early non-invasive cardiac output monitoring in hemodynamically unstable intensive care patients: a multi-center randomized controlled trial. Crit Care. 2011;15:R148.PubMedCentralCrossRefPubMedGoogle Scholar
  43. 43.
    Takala J, Meier-Hellmann A, Eddleston J, Hulstaert P, Sramek V. Effect of dopexamine on outcome after major abdominal surgery: a prospective, randomized, controlled multicenter study. European multicenter study group on dopexamine in major abdominal surgery. Crit Care Med. 2000;28:3417–23.CrossRefPubMedGoogle Scholar
  44. 44.
    Hernandez G, Bruhn A, Luengo C, Regueira T, Kattan E, Fuentealba A, Florez J, Castro R, Aquevedo A, Pairumani R, et al. Effects of dobutamine on systemic, regional and microcirculatory perfusion parameters in septic shock: a randomized, placebo-controlled, double-blind, crossover study. Intensiv Care Med. 2013;39:1435–43.CrossRefGoogle Scholar
  45. 45.
    De Backer D, Creteur J, Dubois MJ, Sakr Y, Koch M, Verdant C, Vincent JL. The effects of dobutamine on microcirculatory alterations in patients with septic shock are independent of its systemic effects. Crit Care Med. 2006;34:403–8.CrossRefPubMedGoogle Scholar
  46. 46.
    Shahin J, DeVarennes B, Tse CW, Amarica DA, Dial S. The relationship between inotrope exposure, six-hour postoperative physiological variables, hospital mortality and renal dysfunction in patients undergoing cardiac surgery. Crit Care. 2011;15:R162.PubMedCentralCrossRefPubMedGoogle Scholar
  47. 47.
    Nielsen DV, Hansen MK, Johnsen SP, Hansen M, Hindsholm K, Jakobsen CJ. Health outcomes with and without use of inotropic therapy in cardiac surgery: results of a propensity score-matched analysis. Anesthesiology. 2014;120:1098–108.CrossRefPubMedGoogle Scholar
  48. 48.
    Tacon CL, McCaffrey J, Delaney A. Dobutamine for patients with severe heart failure: a systematic review and meta-analysis of randomised controlled trials. Intensiv Care Med. 2012;38:359–67.CrossRefGoogle Scholar
  49. 49.
    Rhodes SS, Ropella KM, Camara AK, Chen Q, Riess ML, Pagel PS, Stowe DF. Ischemia-reperfusion injury changes the dynamics of Ca2+—contraction coupling due to inotropic drugs in isolated hearts. J Appl Physiol. 2006;100:940–50.CrossRefPubMedGoogle Scholar
  50. 50.
    Zhou L, Huang H, Yuan CL, Keung W, Lopaschuk GD, Stanley WC. Metabolic response to an acute jump in cardiac workload: effects on malonyl-CoA, mechanical efficiency, and fatty acid oxidation. Am J Physiol Heart Circ Physiol. 2008;294:H954–60.CrossRefPubMedGoogle Scholar
  51. 51.
    Singer M. Catecholamine treatment for shock—equally good or bad? Lancet. 2007;370:636–7.CrossRefPubMedGoogle Scholar
  52. 52.
    Morelli A, Ertmer C, Westphal M, Rehberg S, Kampmeier T, Ligges S, Orecchioni A, D’Egidio A, D’Ippoliti F, Raffone C, et al. Effect of heart rate control with esmolol on hemodynamic and clinical outcomes in patients with septic shock: a randomized clinical trial. JAMA. 2013;310:1683–91.CrossRefPubMedGoogle Scholar
  53. 53.
    Funk DJ, Moretti EW, Gan TJ. Minimally invasive cardiac output monitoring in the perioperative setting. Anesth Analg. 2009;108:887–97.CrossRefPubMedGoogle Scholar
  54. 54.
    Ferreira FL, Bota DP, Bross A, Melot C, Vincent JL. Serial evaluation of the SOFA score to predict outcome in critically ill patients. JAMA. 2001;286:1754–8.CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Gordana Pavlovic
    • 1
  • John Diaper
    • 1
  • Christoph Ellenberger
    • 1
  • Angela Frei
    • 1
  • Karim Bendjelid
    • 1
    • 2
  • Fanny Bonhomme
    • 1
  • Marc Licker
    • 1
    • 2
    Email author
  1. 1.Department of Anaesthesiology, Pharmacology and Intensive CareUniversity Hospital GenevaGenevaSwitzerland
  2. 2.Faculty of medecineUniversity of GenevaGenevaSwitzerland

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