Relations Between Respiratory Changes in R-Wave Amplitude and Arterial Pulse Pressure in Mechanically Ventilated Patients

  • Maxime Cannesson
  • Geoffray Keller
  • Olivier Desebbe
  • Jean-Jacques Lehot



R-wave obtained from the electrocardiogram depends on ventricular stroke volume. We assessed the relationship between respiratory variations in R-wave (ΔRDII) and in pulse pressure (ΔPP) during general anesthesia.


R-wave amplitude was measured from standard lead II (RDII). Maximal RDII (RDIImax) and minimal RDII (RDIImin) were determined over one respiratory cycle. ΔRDII was calculated as 100 × [RDIImax-RDIImin]/([RDIImax + RDIImin]/2. ΔRDII and ΔPP were simultaneously recorded.


There was a significant relationship (r = 0.79; P < 0.001) between ΔRDII and ΔPP. A ΔRDII > 13% detected patients with a ΔPP > 13% with an 89% sensitivity, and an 88% specificity.


ΔRDII and ΔPP are related in this setting.


brody effect fluid responsiveness monitoring non invasive cardiopulmonary interactions 


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The authors wish to thank Max Cho (Medical student, University of California, Irvine, School of Medicine) for English editing.


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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Maxime Cannesson
    • 1
  • Geoffray Keller
    • 2
  • Olivier Desebbe
    • 2
  • Jean-Jacques Lehot
    • 2
  1. 1.Department of Anesthesiology & Perioperative Care, School of MedicineUniversity of California, IrvineOrangeUSA
  2. 2.Hospices Civils de Lyon, Groupement Hospitalier Est, Department of Anesthesiology and Intensive CareLouis Pradel Hospital and Claude Bernard Lyon 1 University, INSERM ERI 22LyonFrance

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