Journal of Clinical Monitoring and Computing

, Volume 21, Issue 6, pp 335–339

Effects of vasodilation on cardiac output measured by PulseCO™

  • Koichi Yamashita
  • Tomoki Nishiyama
  • Takeshi Yokoyama
  • Hidehiro Abe
  • Masanobu Manabe
Article

DOI: 10.1007/s10877-007-9093-9

Cite this article as:
Yamashita, K., Nishiyama, T., Yokoyama, T. et al. J Clin Monit Comput (2007) 21: 335. doi:10.1007/s10877-007-9093-9

Abstract

Backgrounds

The instability of cardiac output (CO) measured by PulseCO™ (LiDCO Ltd.) during cardiac surgery has been reported. In the present study, we investigated the effects of vasodilation by prostaglandin E1 (PGE1) on the relation between cardiac output measured by PulseCO™ and that by thermodilution.

Methods

Twenty patients who underwent off-pump coronary artery bypass grafting (OPCAB) were enrolled in this study. After premedication with oral diazepam 10 mg, anesthesia was induced with midazolam, fentanyl and vecuronium. CO was measured after anesthesia induction, at PGE1 0.01, 0.02 and 0.04 µg/(kg min) and at 15 min after the stop of the infusion.

Results

Systemic vascular resistances (SVRs) by PGE1 at 0.02 and 0.04 µg/(kg min) were significantly lower than the control value. The correlation coefficient (R2) between the two techniques at each point, percentage error and limits of agreement (bias ±2SD of bias) were 0.78, 3, 0.05 ± 0.17 at 0.01 µg/(kg min), 0.20, 10, −0.18 ± 0.12 at 0.02 µg/(kg min), 0.46, 28, −0.50 ± 0.24 at 0.04 µg/(kg min) and 0.97, 1, 0.02 ± 0.27 L/min at 15 min after stop of infusion, respectively.

Conclusion

PulseCO™ might underestimate CO compared to that by bolus thermodilution method when simply decreasing the SVR by infusion of PGE1. Therefore, PulseCO™ might be unsuitable in cardiac surgery.

Keywords

cardiac output pulse contour method thermodilution method prostaglandin E1 vasodilation 

Copyright information

© Springer Science+Business Media B.V. 2007

Authors and Affiliations

  • Koichi Yamashita
    • 1
  • Tomoki Nishiyama
    • 2
  • Takeshi Yokoyama
    • 1
  • Hidehiro Abe
    • 1
  • Masanobu Manabe
    • 1
  1. 1.Department of Anesthesiology and Critical Care MedicineKochi Medical SchoolKochiJapan
  2. 2.Department of Anesthesiology, Faculty of MedicineThe University of TokyoBunkyo-ku,Japan

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