A Heterometallic MOF for Highly Selective Al3+ Ion Detection and Protective Effect Against Periodontitis by Reducing P. gingivalis CFU and Inflammatory Cytokines Levels

  • Yu-Yi Hou
  • Li-Bo Zhou
  • Cun-Fang Meng
  • Jian Guan
  • Guo-Liang Zhang
  • Yu-Ze HouEmail author
Original Paper


By employment of an amide-functionalized tetracarboxylic ligand 5,5′-(carbonylbis(azanediyl))-diisophthalic acid (H4cbab), a new polyhedral metal–organic framework (MOF) with the chemical formula of {[InZn2(cbda)2(H2O)2](NMF)3}n (1, NMF = N-methylformamide) has been synthesized under the solvothermal reaction condition. The structural feature was studied via the single crystal X-ray diffraction along with ultimate analysis. This as-prepared MOF shows excellent luminescence performance which can be able to detect Al3+ ions selectively. In aqueous solutions, the detection limitation for Al3+ ion is 0.56 µM, which is significantly below the highest standard of 7.41 µM for Al3+ ion in drinking water that is defined by the World Health Organization (WHO). The protective effect of compound against periodontitis was further explored. The viable cell counts (CFU) number was counted to evaluate the inhibitory effect of compound on bacterial growth. The enzyme linked immunosorbent assay (ELISA) was carried on in order to measure accurately the proportion of inflammatory cytokines in gingival fluid around the implant. The potential binding modes of the synthesized compounds as well as the targeted protein was explored by calculating docking with high accuracy as well as pose scoring process.


MOF Heterometallic framework Al3+ ion detection Periodontitis Molecular docking 



This work was supported by Grants from Scientific Research Topics of Heilongjiang Health Commission (2018-038).


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Yu-Yi Hou
    • 1
  • Li-Bo Zhou
    • 1
  • Cun-Fang Meng
    • 1
  • Jian Guan
    • 1
  • Guo-Liang Zhang
    • 1
  • Yu-Ze Hou
    • 1
    Email author
  1. 1.Department of StomatologyJiamusi UniversityJiamusiChina

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