Synthesis and Characterization of Cerium Oxide Quantum Dots Loaded Biodegradable Dextran Matrix for Effective Pain Management
The essential intention towards this report is the synthesis and characterization of cerium oxide quantum dots (CeO2 QDs) loaded biodegradable dextran matrix (CED) for the effective pain management in biomedical field. The physic-chemical characterization of CeO2 QDs and CED were carried out using FT-IR, UV–Vis, XPS, TG/DTA, XRD and TEM studies. FT-IR analysis and XPS studies designates the purity of CeO2 QDs and CED without expressing any other excessive peaks. XRD pattern of CeO2 QDs represents the cubic phase structure and thermal analysis confirms the loading of dextran in CED by expressing only one exothermic peak. Morphological characterization like TEM analysis reveals that the particles of CeO2 QDs are in less than < 10 nm and uniform distribution of porous network of dextran in CED. The summary of the in vitro drug releasing and cell viability analysis established that synthesized materials were making favorable entrapment with curcumin molecules at physiological pH conditions and release the drug molecules in the intracellular conditions. Exploited CED with the biocompatible, biodegradable property may improve outcomes profound with the pharmaceutical applications.
KeywordsDextran CeO2 Quantum dots Pain management
This study was supported by Handan Science and Technology Bureau Project (No. 1723208068-7).
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