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Synthesis and Characterization of Cerium Oxide Quantum Dots Loaded Biodegradable Dextran Matrix for Effective Pain Management

  • Hua Guo
  • Tao Liu
  • Jie Li
  • Gangquan ChenEmail author
  • Ping JiaEmail author
Original Paper

Abstract

The essential intention towards this report is the synthesis and characterization of cerium oxide quantum dots (CeO2 QDs) loaded biodegradable dextran matrix (CED) for the effective pain management in biomedical field. The physic-chemical characterization of CeO2 QDs and CED were carried out using FT-IR, UV–Vis, XPS, TG/DTA, XRD and TEM studies. FT-IR analysis and XPS studies designates the purity of CeO2 QDs and CED without expressing any other excessive peaks. XRD pattern of CeO2 QDs represents the cubic phase structure and thermal analysis confirms the loading of dextran in CED by expressing only one exothermic peak. Morphological characterization like TEM analysis reveals that the particles of CeO2 QDs are in less than < 10 nm and uniform distribution of porous network of dextran in CED. The summary of the in vitro drug releasing and cell viability analysis established that synthesized materials were making favorable entrapment with curcumin molecules at physiological pH conditions and release the drug molecules in the intracellular conditions. Exploited CED with the biocompatible, biodegradable property may improve outcomes profound with the pharmaceutical applications.

Keywords

Dextran CeO2 Quantum dots Pain management 

Notes

Acknowledgements

This study was supported by Handan Science and Technology Bureau Project (No. 1723208068-7).

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Aesthetic Plastic SurgeryAffiliated Hospital of Hebei University of EngineeringHandanChina
  2. 2.Department of Medical CosmetologyHebei General HospitalShijiazhuangChina
  3. 3.Department of NephropathyCentral Hospital of Xi’anXi’anChina
  4. 4.Department of BurnThe First Affiliated Hospital of Nanchang UniversityNanchangChina
  5. 5.Department of SICUSichuan Academy of Medical Sciences & Sichuan Provincial People’s HospitalChengduChina
  6. 6.Department of NursingSichuan Provincial People’s Hospital & Qionglai HospitalChengduChina

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