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Phytosynthesis and Characterization of Copper Oxide Nanoparticles using the Aqueous Extract of Beta vulgaris L and Evaluation of their Antibacterial and Anticancer Activities

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Abstract

With an objective of developing sustainable metallic nanoparticles from bioresources, intended for biomedical applications; herein we have fabricated copper oxide nanoparticles through a green chemistry approach. Copper oxide nanoparticles (BvCuONPs) were successfully achieved from an aqueous extract of Beta vulgaris. Synthesized BvCuONPs measure absorbance at 310 nm in UV–Visible Spectrophotometer which is characteristic of copper oxide nanoparticles. Fourier Transform Infrared Spectroscopy (FTIR) identified the responsible functional groups involved in reducing and stabilizing BvCuONPs. Transmission electron microscopy (TEM), atomic force microscopy (AFM) energy dispersive analysis spectroscopy (EDAX) displayed the morphology; crystalline phase and elemental composition of BvCuONPs. Further, we have performed the antibacterial activity of BvCuONPs against tested pathogens. Subsequently, we performed anticancer efficacy of BvCuONPs in A549 cells through cell viability assay and BvCuONPs induce apoptosis in A549 cell line with an IC50 value 25 µg/mL. In addition, BvCuONPs arrest cell cycle in G2/M phase in A549 cells; revealed by flow cytometer analysis. Therefore, it is presumed that BvCuONPs could be developed as a nano drug for infectious diseases and tumor studies.

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References

  1. M. Fakruddin, Z. Hossain, and H. Afroz (2012). J. Nanobiotechnology.10, 31.

    Article  Google Scholar 

  2. K. Khan, I. Saeed, and A. Khan (2017). Arab. J. Chem.. https://doi.org/10.1016/j.arabjc.2017.05.011.

    Article  Google Scholar 

  3. M. Li and S. J. Zinkle Physical and Mechanical Properties of Copper and Copper Alloys. in R. J. M. Konings (ed.), Comprehensive Nuclear Materials, vol. 4 (Elsevier, Amsterdam, 2012), pp. 667–690.

    Chapter  Google Scholar 

  4. C. Rajkuberan, K. Sudha, G. SathishKumar, and S. Sivaramakrishnan (2015). Spectrochim. Acta. A.136, 924–930.

    Article  CAS  Google Scholar 

  5. C. Rajkuberan, S. Prabukumar, G. SathishKumar, K. Ravindran, and A. Wilson (2016). J. Mol. Liq.219, 232–238.

    Article  Google Scholar 

  6. M. Gondwal and G. J. N. Pant (2018). Int. J. Biomater673, 5426.

    Google Scholar 

  7. B. A. Camacho-Flores, O. Martínez-Álvarez, and M. C. Arenas-Arrocena (2015). J. Nanomater.415, 238.

    Google Scholar 

  8. S. Rana and P. T. Kalaichelvan (2013). ISRN. Toxicol.574, 648.

    Google Scholar 

  9. H. Barabadi, B. Tajani, and M. Moradi (2019). J. Clust. Sci.30, 843.

    Article  CAS  Google Scholar 

  10. H. Barabadi, S. Honary, and M. Ali Mohammadi (2017). Environ. Sci. Pollut. Res.24, 5800.

    Article  CAS  Google Scholar 

  11. P. C. Ray, H. Yu, and P. P. Fu (2009). J. Environ. Sci. Health. C. Environ. Carcinog. Ecotoxicol. Rev.27, 1–35.

    Article  CAS  Google Scholar 

  12. S. Honary, H. Barabadi, E. Gharaei-Fathabad, and F. Naghibi (2012). Dig. J. Nanomat. Biostruct.7, 999–1005.

    Google Scholar 

  13. S. Sathiyavimal, S. Vasantharaj, D. Bharathi, M. Saravanan, E. Manikandan, S. S. Kumar, and A. Pugazhendhi (2018). J. Photochem. Photobiol. B.188, 126–134.

    Article  CAS  Google Scholar 

  14. H. C. A. Murthy, B. Abebe, C. H. Prakash, and K. Shantaveerayya (2018). Mat. Sci. Res. India.15, 3.

    Google Scholar 

  15. M. Rastogi and O. Sytar Zivcak (2017). Front. Chem.5, 78.

    Google Scholar 

  16. H. Barabadi, K. Damavandi Kamali, and F. Jazayeri Shoushtari (2019). J. Clust. Sci.. https://doi.org/10.1007/s10876-019-01588-7.

    Article  Google Scholar 

  17. H. Barabadi, M. A. Mahjoub, and B. Tajani (2019). J. Clust. Sci.30, 259.

    Article  CAS  Google Scholar 

  18. H. Barabadi, A. Alizadeh, M. Ovais, A. Ahmadi, Z. Shinwari, and S. Muthupandian (2018). IET. Nanobiotechnol.12, 377–391.

    Article  Google Scholar 

  19. H. Barabadi, M. Ovais, Z. K. Shinwari, and M. Saravanan (2017). Green. Chem. Lett. Rev.10, 285–314.

    Article  CAS  Google Scholar 

  20. A. Ahmad, S. H. Ansari, J. Ahamad, and J. Kamran (2013). Asian J. Biomed. Pharm. Sci.03, 5–10.

    Google Scholar 

  21. T. Clifford, G. Howatson, D. J. West, and E. J. Stevenson (2015). Nutrients.7, 2801–2822.

    Article  CAS  Google Scholar 

  22. S. Prabu Kumar, C. Rajkuberan, and S. Sivaramakrishnan (2018). IET Nanobiotechnol12, 505–508.

    Article  Google Scholar 

  23. P. Yugandhar, T. Vasavi, P. Uma, and M. Devi (2017). Appl. Nanosci.7, 417.

    Article  CAS  Google Scholar 

  24. J. Jana, M. Ganguly, and T. Pal (2016). RSC. Adv.6, 86174–86211.

    Article  CAS  Google Scholar 

  25. M. S. Jadhav, S. Kulkarni, P. Raikar, D. A. Barretto, S. Kumar Vootlac, and U. S. Raikar (2018). New. J. Chem.42, 204–213.

    Article  CAS  Google Scholar 

  26. V. Sharma, C. Chotia, V. Ganesan, and G. S. Okram (2017). Phys. Chem. Chem. Phys.19, 14096–14106.

    Article  CAS  Google Scholar 

  27. M. G. Miguel (2018). Antioxidants.7, 53.

    Article  Google Scholar 

  28. C. M. Phan and H. M. Nguyen (2017). J. Phys. Chem. A.121, 3213–3219.

    Article  CAS  Google Scholar 

  29. Y. N. Slavin, J. Asnis, U. O. Häfeli, and H. Bach (2017). J. Nanobiotechnology.15, 65.

    Article  Google Scholar 

  30. L. Wang, C. Hu, and L. Shao (2017). Int. J. Nanomedicine.12, 1227–1249.

    Article  CAS  Google Scholar 

  31. M. J. Hajipour, K. M. Fromm, A. A. Ashkarran, D. J. De Aberasturi, I. R. De Larramendi, and T. Rojo (2012). Trends. Biotechnol.10, 499–511.

    Article  Google Scholar 

  32. S. Meghana, P. Kabra, S. Chakraborty, and N. Padmavathy (2015). RSC. Adv.15, 12293–12299.

    Article  Google Scholar 

  33. K. Kanagamani, P. Muthukrishnan, and K. Shankar (2019). J. Clust. Sci.. https://doi.org/10.1007/s10876-019-01583-y.

    Article  Google Scholar 

  34. I. A. Wongrakpanich and S. M. Geary Mudunkotuwa (2016). Environ. Sci. Nano.3, 365–374.

    Article  CAS  Google Scholar 

  35. R. Sankar, R. Maheswari, S. Karthik, K. S. Shivashangari, and V. Ravikumar (2014). Mater. Sci. Eng. C. Mater. Biol. Appl.44, 234–239.

    Article  CAS  Google Scholar 

  36. G. Sulaiman, A. T. Tawfeeq, and M. D. Jaaffer (2018). Biotechnol. Prog.34, 218–230.

    Article  CAS  Google Scholar 

  37. S. Honary and F. Zahir (2013). Trop. J. Pharm. Res.12, 265–273.

    Google Scholar 

  38. S. Saif, A. Tahir, T. Asim, and Y. Chen (2016). Nanomaterials.6, 205.

    Article  Google Scholar 

  39. S. Dey, S. Manna, D. Chattopadhyay, D. Mondal, A. Chattopadhyay, S. Raj, and R. Roy (2019). J. Saudi. Chem. Soc.23, 222–238.

    Article  CAS  Google Scholar 

  40. M. Shafagh, F. Rahmani, and N. Delirezh (2015). Iran. J. Basic. Med. Sci.18, 993–1000.

    PubMed  PubMed Central  Google Scholar 

  41. V. Ramalingam, S. Revathidevi, T. Shanmuganayagam, L. Muthulakshmic, and R. Rajaram (2016). RSC. Adv.6, 20598–20608.

    Article  CAS  Google Scholar 

  42. V. Ramalingam, S. Revathidevi, T. Shanmuganayagam, L. Muthulakshmic, and R. Rajaram (2017). Gold. Bull.50, 177.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Biotechnology, Karpagam Academy of Higher Education, Coimbatore, India

    Rajkuberan Chandrasekaran & Sangilimuthu Alagar Yadav

  2. Department of Biotechnology, Bharathidasan University, Tiruchirappalli, India

    Sivaramakrishnan Sivaperumal

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  1. Rajkuberan Chandrasekaran
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  2. Sangilimuthu Alagar Yadav
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  3. Sivaramakrishnan Sivaperumal
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Correspondence to Rajkuberan Chandrasekaran.

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Chandrasekaran, R., Yadav, S.A. & Sivaperumal, S. Phytosynthesis and Characterization of Copper Oxide Nanoparticles using the Aqueous Extract of Beta vulgaris L and Evaluation of their Antibacterial and Anticancer Activities. J Clust Sci 31, 221–230 (2020). https://doi.org/10.1007/s10876-019-01640-6

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