Emerging Theranostic Silver and Gold Nanomaterials to Combat Prostate Cancer: A Systematic Review

  • Hamed BarabadiEmail author
  • Kaveh Damavandi Kamali
  • Fereshteh Jazayeri Shoushtari
  • Babak Tajani
  • Mohammad Ali Mahjoub
  • Ahad Alizadeh
  • Muthupandian SaravananEmail author
Review Paper


Prostate cancer has emerged as the common malignancy in men and is considered as a global issue. Among different strategies to combat prostate cancer, nanobiotechnology appears as a novel approach for prostate cancer theranostics. The current systematic review discussing the recent development in the prostate anticancer activity of biologically synthesized silver nanoparticles (AgNPs) and gold nanoparticles (AuNPs) through laboratory investigations. The databases including Cochrane, Web of Science, PubMed, Scopus, Science Direct, ProQuest, and Embase were used to identify the records. It was found that most of the studies used herbal extracts for preparation of AgNPs and/or AuNPs. Majority of biosynthesized nanoparticles (NPs) were formed with spherical morphology. Besides, all studies reported the size of NPs less than 100 nm. Moreover, PC-3 prostate cancer cell was the predominant cell line that was evaluated for prostate anticancer activity of NPs. In the present study, we provided valuable information suggesting the significant prostate anticancer potential of biogenic AgNPs and/or AuNPs. However, further, in vivo investigations are required to provide stronger evidence of the efficacy of bio-mediated synthesized AgNPs and/or AuNPs to combat prostate cancer.


Prostate cancer Cancer nanomedicine Silver nanoparticles Gold nanoparticles 


Compliance with Ethical Standards

Conflict of interest

The authors declare that they have no conflict of interest.


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Authors and Affiliations

  1. 1.Department of Pharmaceutical Biotechnology, School of PharmacyShahid Beheshti University of Medical SciencesTehranIran
  2. 2.Golestan University of Medical Sciences, Food and Drug AdministrationGorganIran
  3. 3.School of PharmacyAhvaz Jundishapur University of Medical SciencesAhvazIran
  4. 4.Department of Pharmaceutics, School of PharmacyShahid Beheshti University of Medical SciencesTehranIran
  5. 5.Department of Epidemiology and Biostatistics, School of Public HealthTehran University of Medical SciencesTehranIran
  6. 6.Department of Medical Microbiology and Immunology, Division of Biomedical Sciences, School of Medicine, College of Health SciencesMekelle UniversityMekelleEthiopia

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