Evaluation of Antibacterial and Anticancer Potential of Polyaniline-Bimetal Nanocomposites Synthesized from Chemical Reduction Method
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This study gold (Au) and gold–platinum (Au–Pt) colloids were synthesized by borohydride reduction method in the presence of poly(N-vinyl-2-pyrrolidone) as a stabilizing agent. Besides, pristine polyaniline (PANI), PANI-Au nanocomposites, and PANI-Au–Pt nanocomposites were prepared. The synthesized nano-composites characterized by UV–Vis, FT-IR, XRD, and HR-TEM with energy dispersive X-ray techniques. Au and Au–Pt NPs were spherical in shape with particle sizes at 8 and 3 nm, respectively. PANI-Au and PANI-Au–Pt nanocomposites were also spherical in shape with particle sizes at 3 and 2 nm, respectively. Pristine PANI, PANI-Au, and PANI-Au–Pt nanocomposites were subjected to antibacterial activity against gram-positive (Bacillus subtilis and Staphylococcus aureus) and gram-negative (Escherichia coli and Vibrio cholerae) bacterial pathogens. PANI-Au–Pt nanocomposite showed significant antibacterial activity (33 ± 1.10 mm dia) against B. subtilis. Besides, the MIC of pristine PANI, PANI-Au, and PANI-Au–Pt nanocomposites were found to be 75, 50 and 25 µg/mL, respectively. Besides, the in vitro anticancer investigations against HepG2 liver cancer cells revealed the highest cytotoxicity for PANI-Au–Pt nanocomposite (21.25 µg/mL) followed by PANI-Au nanocomposite (32 µg/mL) and pristine PANI (49 µg/mL). Overall, the present study showed considerable antibacterial and anticancer activity and suggested their potential use in pharmaceuticals after completing successful clinical trials for safety and affordability.
KeywordsPolyaniline-bimetal Nanocomposite Antibacterial activity Clinical pathogens Anticancer activity
The authors thank University Grants Commission, New Delhi for providing Assistant professor (No. F. 14-13/2013 (Inno/ASIST) dated 30.03.2013) under the Innovative scheme to carry out the teaching and research work. The authors thankfully acknowledge the DST-FIST [SR/FST/LSI-667/2016(C)], DST-PURSE [SR/PURSE Phase 2/38 (G)] and MHRD-RUSA 2.0 [F. 24/51/2014-U, Policy (TNMulti-Gen), Dept. of Edn. Govt. of India] for the financial supports and infrastructure facilities. The authors (H. Gurumallesh Prabu) acknowledge the UGC-BSR, New Delhi, India for the financial assistance by the onetime grant scheme.
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Conflict of interest
The authors declare that they have no conflict of interests.
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