Synthesis of Plant Latex Based Hybrid Nanocarriers Using Surfactants for Curcumin Delivery
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Plants exude polymer particles through a white sap known as the latex. These latexes are complex mixtures that consist of polar and non-polar components. Extracting these components using different polarity solvents and re-mixing with surfactants results in the formation of nanoparticles. In this study, latex from Euphorbia antiquorum and Calotropis gigantea was collected. Polar and non-polar components were extracted using water and benzene respectively and characterized by UV–Vis spectrometry, FTIR and GC–MS. Both the polar and non polar extracts together were subjected for nanocarrier synthesis using surfactants (Triton X, SDS, CTAB, TWEEN 20 and SPAN 20) by sample emulsion solvent evaporation technique. The obtained nanocarrier was characterized using different analytical techniques like UV Vis, FTIR, SEM, AFM. The nanocarriers were also loaded with curcumin and subjected for drug delivery studies invitro. Using the latex of C. gigantea and E. antiquorum, curcumin loaded nanoparticles of size 300 nm was produced. Triton X was producing smaller nanoparticles and all the nanoparticles were releasing the loaded curcumin in acidic environment only.
KeywordsEuphorbia antiquorum Calotropis gigantea Latex Hybrid nanocarriers Drug delivery
Compliance with Ethical Standards
Conflict of interest
All the authors of this paper have no conflict of interest.
- 5.J. Sivakumar, C. Premkumar, P. Santhanam, and N. Saraswathi (2011). Afr. J. Basic Appl. Sci. 39, 265.Google Scholar
- 6.D. Pratik, P. Rohan, D. Kailas, H. Anup, and D. Pushpa (2015). Int. J. Sci. Res. (IJSR) 4, 340.Google Scholar
- 8.P. K. Sake, Rajeswari, V. Reddy, A. G. Damu, and S. V. P. S. Khan (2013). Indian J. Adv. Chem. Sci. 1, 117.Google Scholar
- 22.R. P. Pawar (2017). World J. Pharmaceut. Life Sci. 2, 590.Google Scholar
- 23.A. Khusro, C. Aarti, J. P. Preetamraj, and S. G. Panicker (2014). Int. J. Pharm. Pharmaceut. Sci. 6.Google Scholar
- 25.N. Ramamurthy and S. Kannan (2007). Rom. J. Biophys. 17, 269.Google Scholar
- 26.M. K. K. Ahmed, A. C. Rana, and V. K. Dixit (2005). Pharmacogn. Mag. 1, 48.Google Scholar
- 29.S. Sharma, A. Kumari, and M. Sharma (2016). Int. J. Pharmacogn. Phytochem. Res. 8, 1823.Google Scholar
- 31.A. V. Samrot, B. Suvedhaa, C. S. Sahithya, and A. M. Kumar (2018). J. Cluster Sci. 1. https://doi.org/10.1007/s10876-018-1412-4.