Journal of Cluster Science

, Volume 30, Issue 1, pp 11–24 | Cite as

Utilization of Chemically Synthesized Super Paramagnetic Iron Oxide Nanoparticles in Drug Delivery, Imaging and Heavy Metal Removal

  • P. Durga Sruthi
  • Chamarthy Sai Sahithya
  • C. Justin
  • C. SaiPriya
  • Karanam Sai Bhavya
  • P. Senthilkumar
  • Antony V. SamrotEmail author
Original Paper


In this study, Super Paramagnetic Iron Oxide Nanoparticles (SPIONs) were produced by chemical co-precipitation method. The produced SPIONs were exploited for the production of core–shell SPIONs for drug delivery against bacteria and cancer cells, while the naked SPIONs were used as contrasting agent in X-ray imaging and also for heavy metal removal. Core–shell SPIONs were prepared by a series of steps comprising the synthesis by chemical co-precipitation method, functionalized with a surfactant, followed by coating with drug—itraconazole and encapsulation with biopolymer (either with Polyhydroxybutyrate or polysaccharide derived from Terminalia catappa). Further characterization of these core–shell SPIONs was done with various microscopic and spectroscopic analyses. Drug encapsulation and release efficiency were studied. In-vitro drug release efficiency was assessed by antibacterial activity and anticancer activity. Further, the ability of the SPIONs as contrasting agent in X-ray imaging and heavy metal removal was also assessed.


SPIONs Chemical co-precipitation Surfactant Biopolymer coating Contrasting agent 



The work was not supported by any funding agency.

Compliance with Ethical Standards

Conflict of interest

The authors have no conflict of interest.


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • P. Durga Sruthi
    • 1
  • Chamarthy Sai Sahithya
    • 1
  • C. Justin
    • 1
  • C. SaiPriya
    • 1
  • Karanam Sai Bhavya
    • 1
  • P. Senthilkumar
    • 2
  • Antony V. Samrot
    • 1
    Email author
  1. 1.Department of Biotechnology, School of Bio and Chemical EngineeringSathyabama Institute of Science and TechnologyChennaiIndia
  2. 2.Department of Chemical Engineering, School of Bio and Chemical EngineeringSathyabama Institute of Science and TechnologyChennaiIndia

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