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Journal of Cluster Science

, Volume 29, Issue 6, pp 989–1002 | Cite as

Purification and Utilization of Gum from Terminalia Catappa L. for Synthesis of Curcumin Loaded Nanoparticle and Its In Vitro Bioactivity Studies

  • Antony V. Samrot
  • B. Suvedhaa
  • Chamarthy Sai Sahithya
  • A. Madankumar
Original Paper
  • 77 Downloads

Abstract

In this study, polysaccharide of Terminalia catappa L. was extracted and characterized using UV–Vis spectroscopy and FTIR spectroscopy. The polysaccharide was tested for its antibacterial activity, swarming motility, antibiofilm activity, anticancer activity and antioxidant activity. Further, the polysaccharide was subjected for carboxymethylation and chelated using Tri Sodium Tri Meta phosphate to form nanocarriers. The nanocarriers were loaded with curcumin and were characterized using FTIR, SEM, EDAX, TEM and AFM. The curcumin nanocarriers were evaluated for its drug encapsulation efficiency, drug release, invitro anticancer activity and also subjected for cellular uptake studies. The polysaccharide was found to be producing a stable and non hemotoxic nanocarrier, which could encapsulate drug and release drug efficiently.

Keywords

Almond gum polysaccharide (AGP) Carboxymethylated AGP (CMAG) Nanocarrier Curcumin Cellular uptake 

Notes

Compliance with Ethical Standards

Conflict of interest

The authors have no conflict of interest.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Antony V. Samrot
    • 1
  • B. Suvedhaa
    • 1
  • Chamarthy Sai Sahithya
    • 1
  • A. Madankumar
    • 2
  1. 1.Department of Biotechnology, School of Bio and Chemical EngineeringSathyabama Institute of Science and TechnologyChennaiIndia
  2. 2.Molecular and Nanomedicine Research UnitSathyabama Institute of Science and TechnologyChennaiIndia

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