Journal of Cluster Science

, Volume 29, Issue 4, pp 743–755 | Cite as

Cost Effective, Green Synthesis of Copper Oxide Nanoparticles Using Fruit Extract of Syzygium alternifolium (Wt.) Walp., Characterization and Evaluation of Antiviral Activity

  • Pulicherla Yugandhar
  • Thirumalanadhuni Vasavi
  • Yagani Jayavardhana Rao
  • Palempalli Uma Maheswari Devi
  • Golla Narasimha
  • Nataru Savithramma
Original Paper


The present study was aimed to synthesize copper oxide nanoparticles (CuO NPs) using fruit extract of Syzygium alternifolium and to evaluate their antiviral activity against Newcastle Disease Virus (NDV). The CuO NPs synthesized, were characterized by employing different spectroscopic and microscopic tools. The peak manifested at 285 nm in UV–Vis analysis confirms the synthesis of CuO NPs. FTIR analysis showed two conspicuous peaks at 3253 and 1461 cm−1 which correspond to O–H stretch of phenols and N–H bond of primary amines of proteins respectively. This result confirms their involvement in capping and stabilization of nanoparticles. The DLS and zeta potential studies revealed 61.1 nm average size and − 49.2 mV of zeta potential (ζ) value. The XRD crystallography investigations exhibited end-centered monoclinic crystalline nature nanoparticles with 17.5 nm average size. The microscopic (AFM, SEM, TEM) analyses unveiled spherical shaped particles with 2–69 nm size of the CuO NPs. These nanoparticles were settled in poly-dispersed and non-agglomerated state. They exhibited potential growth inhibitory effect on NDV virus. Based on the results of present work it can be emphasized that nanoparticles synthesized using plant extracts find a place in future nanomedicine.


Syzygium alternifolium Green synthesis CuO NPs Characterization Antiviral activity 



The first author is thankful to University Grants Commission-Basic Science and Research for providing fellowship. All the authors are greatly acknowledged to SAIF-IIT Madras, JNTU-Hyderabad, DST-PURSE-SVU-Tirupati for providing instrumentation facilities. Finally thanking to Prof. K. Suma Kiran, Department of English, S.V. University for revising the manuscript.

Compliance with Ethical Standards

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Pulicherla Yugandhar
    • 1
  • Thirumalanadhuni Vasavi
    • 2
  • Yagani Jayavardhana Rao
    • 3
  • Palempalli Uma Maheswari Devi
    • 2
  • Golla Narasimha
    • 3
  • Nataru Savithramma
    • 1
  1. 1.Department of BotanySri Venkateswara UniversityTirupatiIndia
  2. 2.Department of Applied MicrobiologySri Padmavati Mahila VisvavidyalayamTirupatiIndia
  3. 3.Department of VirologySri Venkateswara UniversityTirupatiIndia

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