Interstitial Lung Disease Frequently Precedes CVID Diagnosis
- 65 Downloads
To the editor:
Common variable immunodeficiency disorder (CVID) is the most frequent clinically relevant primary immunodeficiency, and pulmonary infections, often leading to the development of bronchiectasis, are a major clinical finding in CVID patients . However, non-infectious manifestations of the lung occur frequently too, with previous studies reporting interstitial lung diseases (ILD) in 10–20% of patients with CVID [1, 2, 3] and a disease onset of non-infectious pulmonary manifestations after 8 years . CVID patients suffering from ILD have a poorer clinical prognosis . Due to its main clinical manifestations, the term “granulomatous lymphocytic interstitial lung disease (GLILD)” was coined; however, clinical and histopathological findings show substantial heterogeneity, and a clear and universal definition is missing.
Other non-infectious manifestations, like immune thrombocytopenia or autoimmune hemolytic anemia, often precede the clinical symptoms and diagnosis of...
Compliance with Ethical Standards
Conflict of Interest
The authors declare that they have no conflict of interest.
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.
Informed consent was obtained from all individual participants included in the study.