Journal of Clinical Immunology

, Volume 39, Issue 8, pp 836–838 | Cite as

Unusual Severe Seborrheic Dermatitis in Two Siblings with Autosomal Recessive Chronic Granulomatous Disease

  • Nuria B. Zurro
  • Edgar B. de Oliveira Junior
  • Tábata T. França
  • Vera M. Dantas
  • Jose A. Tavares de Albuquerque
  • Antonio Condino-NetoEmail author
Letter to Editor

To the Editor

Dermatitis generally presents in the eczematous form in eyelids, periorbital skin, nares, perioral skin, and ears. There are several types of dermatitis classified based on clinical presentation and characteristics. Seborrheic dermatitis (SD) or seborrhea is an inflammatory skin disease whose pathophysiology is not completely understood. In infants, SD usually presents as yellow scales on the scalp, while in adolescents and adults, it typically presents as flaky, greasy, erythematous patches on the scalp, nasolabial folds, anterior chest, or upper back. The identification of SD is based on the location and appearance of the lesions, and the skin biopsy usually reveals the presence of epidermal parakeratosis and spongiosis [ 1]. Primary immunodeficiencies (PID) are inborn errors of immunity that lead to susceptibility to infections. Skin manifestations are present in approximately 40% of pediatric cases of PID [ 2]. Chronic granulomatous disease (CGD) is a PID caused by...



We thank our patient and his family for their participation in this study. We thank Instituto PENSI for administrative support.


This work was supported by CAPES to NBZ; The Jeffrey Modell Foundation to ACN; and PENSI Institute and Ministério da Saúde do Brasil (PRONAS/PDC 2015, 25000.077928/2015-6) to ACN.

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.

Ethics Committee

This study was approved by the Ethics and Research Committee for Humans at the Institute of Biomedical Sciences, University of São Paulo, in accordance with the Declaration of Helsinki. Patients or parents provided written informed consent.


  1. 1.
    Clark GW, Pope SM, Jaboori KA. Diagnosis and treatment of seborrheic dermatitis. Am Fam Physician. 2015;91:185–90.PubMedGoogle Scholar
  2. 2.
    Berron-Ruiz L, Morin-Contreras A, Cano-Garcia V, Yamazaki-Nakashimada MA, Gomez-Tello H, et al. Detection of inheritance pattern in thirty-three Mexican males with chronic granulomatous disease through 123 dihydrorhodamine assay. Allergol Immunopathol (Madr). 2014;42:580–5.CrossRefGoogle Scholar
  3. 3.
    Luis-Montoya P, Saez-de Ocariz Mdel M, Vega-Memije ME. Chronic granulomatous disease: two members of a single family with different dermatologic manifestations. Skinmed. 2005;4:320–2.CrossRefGoogle Scholar
  4. 4.
    Vazquez N, Lehrnbecher T, Chen R, Christensen BL, Gallin JI, et al. Mutational analysis of patients with p47-phox-deficient chronic granulomatous disease: the significance of recombination events between the p47-phox gene (NCF1) and its highly homologous pseudogenes. Exp Hematol. 2001;29:234–43.CrossRefGoogle Scholar
  5. 5.
    de Oliveira-Junior EB, Zurro NB, Prando C, Cabral-Marques O, Pereira PV, Schimke LF, Klaver S, Buzolin M, Blancas-Galicia L, Santos-Argumedo L, Pietropaolo-Cienfuegos DR, Espinosa-Rosales F, King A, Sorensen R, Porras O, Roxo-Junior P, Forte WC, Orellana JC, Lozano A, GalicchioM, Regairaz L, Grumach AS, Costa-Carvalho BT, Bustamante J, Bezrodnik L, Oleastro M, Danielian S, Condino-Neto. Clinical and genotypic spectrum of chronic granulomatous disease in 71 Latin American patients: first report from the LASID registry. A Pediatr Blood Cancer. 2015;62:2101–7.CrossRefGoogle Scholar
  6. 6.
    Kamamoto CSL, Nishikaku AS, Gompertz OF, Melo AS, Hassun KM, et al. Cutaneous fungal microbiome: Malassezia yeasts in seborrheic dermatitis scalp in a randomized, comparative and therapeutic trial. Dermatoendocrinol. 2017;9:e1361573.CrossRefGoogle Scholar
  7. 7.
    Park JH, Park YJ, Kim SK, Kwon JE, Kang HY, Lee ES, et al. Histopathological differential diagnosis of psoriasis and seborrheic dermatitis of the scalp. Ann Dermatol. 2016;28:427–32.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Immunology, Institute of Biomedical SciencesUniversity of São PauloSão PauloBrazil
  2. 2.Department of PediatricsFederal University of Rio Grande do NorteNatalBrazil

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