Fifteen Years of the J Project
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Over the past 15 years, remarkable progress has been made of clinical care, laboratory diagnosis, and in particular, genetics in the field of primary immunodeficiency diseases (PIDs) . This progress resulted mostly from a better understanding of the relationship between genotype and phenotype variability in patients with “normal” immunity and in those with increased susceptibility to infection, inflammatory and autoimmune disorders, allergy, and cancer . The wondrous unraveling of the human genome sequence by virtue of the human genome project from 1991 to 2004, and later on by other international collaborative projects like HapMap, 1000 genome project, and ENCODE, has opened the way to the rapid development of the field . Introduction of new generation sequencing (NGS), whole genome sequencing (WGS), and whole exome sequencing (WES) in 2010 revolutionized the diagnosis and research of PIDs leading to the discovery of hundreds of novel inborn errors of immunity . Progress...
We thank the members of the JP Steering Committee for ongoing support and commitment to the J Project. We thank PID laboratories in Western Europe and the USA, especially the European Lab in Paris and New York headed by J-L Casanova for their generous help to molecular analysis of samples from PID patients in ECE. The J Project has been supported by educational grants for many years by Biotest Hungaria Kft, Biotest GmbH, later on by Octapharma Nordic, Kedrion and Baxter, and recently by the Shire and Grifols. The close relationship and professional collaboration with the ESID, the JMF, and the FCI were indispensable to run successfully the J Project. We acknowledge the constant interest and intellectual support of the whole PID community all over the world. We thank J-L Casanova and HD Ochs for helpful comments.
Collaborators: Abolhassani, Hassan (Tehran, Iran); Aghamohamaddi, Asghar (Tehran, Iran); Avcin, Tadej (Ljubljana, Slovenia); Bataneant, Michaela (Timisoara, Romania); Belevtsev, Michail (Minsk, Belarus); Bernatowska, Ewa (Warsaw, Poland); Bolkov, Michael (Yekaterinburg, Russia); Bondarenko, Anastasia (Kiev, Ukraine); Caliskaner, Zafer (Konya, Turkey); Chernyshova, Liudmyla (Kiev, Ukraine); Ciznar, Peter (Bratislava, Slovakia); El-Marsafy, Aisha (Cairo, Egypt); Erdős, Melinda (Debrecen, Hungary); Galal, Nereen; (Cairo, Egypt); Guseva, Marina (St. Petersburg, Russia); Iritsyan, Sevan (Yerevan, Armenia); Ismaili-Jaha, Vlora (Pristhina, Kosovo); Kelecic, Jadranka (Zagreb, Croatia); Kondratenko, Irina (Moscow, Russia); Kostyuchenko, Larysa (Lviv, Ukraine); Kovzel, Elena (Astana City, Kazakhstan); Kuli-Lito, Georgina (Tirana, Albania); Lázár, István (Debrecen, Hungary); Litzman, Jiri (Brno, Czech Republic); Mironska, Kristina (Skopje, Republic of Macedonia); Mulaosmanovich, Velma (Sarajevo, Bosnia-Herzegovina); Naumova, Elissaveta (Sofia, Bulgaria); Nashrullayeva, Gulnara (Baku, Azerbaijan); Pac, Malgorzata (Warsaw, Poland); Pagava, Karaman (Tbilisi, Georgia); Pasic, Srdjan (Beograd, Serbia); Pischalnikov, Alexander (Chelyabinsk, Russia); Prokofjeva, Tatjana (Riga, Latvia); Reisli, Ismail (Konya, Turkey); Resaei, Nima (Tehran, Iran); Ress, Krista (Tallin, Estonia); Savchak, Ihor (Lviv, Ukraine); Sciuca, Svetlana (Chisinau, Republic of Moldova); Sediva, Anna (Prague, Czech Republic); Serban, Margit (Timisoara, Romania); Sharapova, Svetlana (Minsk, Belarus); Sitkauskiene, Brigita (Kaunas, Lithuania); Skomska, Malgosia (Warsaw, Poland); Szolnoky, Miklós (Budapest, Hungary); Tóth, Beáta (Debrecen, Hungary); Totolian, Areg (St. Petersburg, Russia); Tuzankina, Irina (Yekaterinburg, Russia); Vamos, Katalin (Budapest, Hungary); Volokha, Alla (Kiev, Ukraine).
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Conflict of Interest
The authors declare that they have no conflict of interest.
- 3.Antonarakis SE. Human genome sequence and variation. In: Speicher MR, Antonarakis SE, Motulsky AG, editors. Vogel and Motulsky’s human genetics: Springer; 2010. p. 31–53.Google Scholar