Granule Cell Neuronopathy in a Patient with Common Variable Immunodeficiency
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To the Editor,
The JC virus or John Cunningham virus is a member of the polyomavirus family found only in humans. Initial infection occurs mainly in childhood, and is usually asymptomatic. The virus establishes lifelong latent infection in a range of tissues, including the brain. JC virus is recognised as the cause for progressive multifocal leukoencephalopathy (PML), an often-devastating central nervous system infection resulting from reactivation of latent virus, almost exclusively seen in immunosuppressed patients. Whereas PML results from JC virus infection of brain glial cells, infection of granule neurons in the cerebellum results in granule cell neuronopathy (GCN). We report a common variable immunodeficiency (CVID) patient who developed GCN, and who clinically improved with mirtazapine and mefloquine.
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Conflict of Interest
The authors declare that they have no conflict of interest.
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