Renal Disease in Chronic Granulomatous Disease: Data from the USIDNET Registry
To the editor:
Chronic granulomatous disease (CGD) is a primary immunodeficiency caused by mutations in genes encoding NADPH oxidase complex protein subunits, which leads to skin and soft tissue infection, pneumonia, abscesses, and granulomatous inflammation all of which could be life-threatening . Prophylactic antimicrobials are the mainstay of treatment for CGD. Some of these antimicrobials are nephrotoxic and may lead to end-stage renal disease (ESRD) . The aim of our study was to assess the prevalence of ESRD in CGD patients using the USIDNET registry.
We queried the USIDNET database on 28 March 2017 requesting demographic data on CGD patients, number of CGD patients who required renal replacement therapy (hemodialysis and transplant) and timeline to renal replacement therapy from CGD diagnosis. A second query on 02 May 2017 requested all antimicrobials (drug, indication, dose, outcome, complications) received by patients identified in the first query to have had a diagnosis...
We gratefully acknowledge The U.S. Immunodeficiency Network (USIDNET), a program of the Immune Deficiency Foundation (IDF), which is supported by a cooperative agreement, U24AI86837, from the National Institute of Allergy and Infectious Diseases (NIAID).
We acknowledge the enrolling physicians for the USIDNET:
Zuhair K Ballas
Kathryn M Edwards
Harry L Malech
Paul G Quie
Andrew H Urbach
Compliance with Ethical Standards
Conflict of Interest
The authors declared that they have no conflict of interest.