Impact of Using Different Response Criteria for Pneumococcal Polysaccharide Vaccination for Assessment of Humoral Immune Status
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To the editor:
Polysaccharide vaccination can be used to assess the functional status of the humoral immune system. An impaired response to vaccination supports the diagnosis of an antibody deficiency. Current diagnostic criteria for common variable immunodeficiency and specific antibody deficiency include documentation of an impaired response to polysaccharide vaccination .
The criteria for interpreting pneumococcal polysaccharide antibody responses, using pre- and post-vaccination antibody levels, have changed over the years [1, 2]. Because few studies have evaluated these criteria in healthy adults, they are mostly based on expert opinion. Interpretation of the changes in antibody levels can be based on a combination of the following: (1) the increase in specific antibody levels over pre-immunization concentrations, (2) the final concentration of antibodies after immunization, and (3) the percentage of serotypes to which the patient responded. For each of these three criteria, a...
We thank Prof. Xavier Bossuyt for providing the raw data on vaccination responses in the Belgian cohorts.
Compliance with Ethical Standards
Conflict of Interest
The authors declare that they have no conflicts of interest.
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