Journal of Clinical Immunology

, Volume 33, Issue 6, pp 1043–1056

Chronic Recurrent Multifocal Osteomyelitis

Key Review Article

DOI: 10.1007/s10875-013-9902-5

Cite this article as:
Costa-Reis, P. & Sullivan, K.E. J Clin Immunol (2013) 33: 1043. doi:10.1007/s10875-013-9902-5


Chronic recurrent multifocal osteomyelitis is a rare auto-inflammatory condition that primarily affects children and adolescents. It presents with recurrent episodes of pain related to the presence of foci of sterile bone inflammation. The long bones of the lower extremities are more frequently affected and the spine can also be involved. Imaging studies, including whole-body magnetic resonance, are important for diagnosis and detection of asymptomatic lesions. Bone biopsies may be necessary to exclude other diseases, including malignancy and infections. Non-steroidal anti-inflammatory drugs cause relief of symptoms in the majority of cases. Bisphosphonates and TNF-α blockers are alternatives for patients who do not respond or who have spinal involvement.


CRMO chronic recurrent multifocal osteomyelitis 

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.The Children’s Hospital of PhiladelphiaPhiladelphiaUSA
  2. 2.Divisions of Allergy and Immunology and RheumatologyChildren’s Hospital of PhiladelphiaPhiladelphiaUSA

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