Journal of Clinical Immunology

, Volume 33, Issue 4, pp 725–730 | Cite as

Diabetes, Renal and Cardiovascular Disease in p47phox−/− Chronic Granulomatous Disease

  • Jennifer W. Leiding
  • Beatriz E. Marciano
  • Christa S. Zerbe
  • Suk See DeRavin
  • Harry L. Malech
  • Steven M. Holland
Original Research

Abstract

Chronic granulomatous disease is a rare immunodeficiency due to defects in the phagocyte NADPH oxidase. The X-linked form (gp91phox deficiency) accounts for about 70 % of cases; autosomal recessive p47phox deficiency accounts for about 25 % of cases. We identified a 10 % incidence of diabetes in p47phox deficient CGD, but none in X-linked CGD. Renal and cardiovascular diseases were also higher in p47phox deficiency. p47phox deficient CGD has non-infectious morbidities distinct from those in X-linked CGD.

Keywords

Chronic granulomatous disease p47phox diabetes kidney renal 

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Copyright information

© Springer Science+Business Media New York (outside the USA) 2013

Authors and Affiliations

  • Jennifer W. Leiding
    • 1
    • 3
  • Beatriz E. Marciano
    • 1
  • Christa S. Zerbe
    • 1
  • Suk See DeRavin
    • 2
  • Harry L. Malech
    • 2
  • Steven M. Holland
    • 1
  1. 1.Laboratories of Clinical Infectious DiseasesNational Institutes of HealthBethesdaUSA
  2. 2.Host Defenses, National Institute of Allergy and Infectious DiseasesNational Institutes of HealthBethesdaUSA
  3. 3.Department of Pediatrics, Division of Allergy, Immunology, and RheumatologyUniversity of South FloridaSt. PetersburgUSA

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