Journal of Clinical Immunology

, Volume 32, Issue 2, pp 268–280

Immune Reconstitution Following Unmanipulated HLA-Mismatched/Haploidentical Transplantation Compared with HLA-Identical Sibling Transplantation

  • Ying-Jun Chang
  • Xiang-Yu Zhao
  • Ming-Rui Huo
  • Lan-Ping Xu
  • Dai-Hong Liu
  • Kai-Yan Liu
  • Xiao-Jun Huang
Article

DOI: 10.1007/s10875-011-9630-7

Cite this article as:
Chang, YJ., Zhao, XY., Huo, MR. et al. J Clin Immunol (2012) 32: 268. doi:10.1007/s10875-011-9630-7

Abstract

In this study, we prospectively investigated the immune reconstitution in patients with hematological malignancies after human leukocyte antigen (HLA)-mismatched/unmanipulated haploidentical transplantation (50 cases) and HLA-matched transplant (25 cases). Transplant-related mortality, relapse, leukemia-free survival, and overall survival were similar between the two transplant strategies, although the cumulative incidence of CMV antigenemia was significantly higher in haploidentical recipients than in HLA-matched recipients (49.9 ± 7.2% versus 13 ± 7%, P = 0.007). Compared with HLA-matched recipients, T-cell subset and dendritic cell subgroup cell counts in the first 90 days after grafting were lower in haploidentical recipients. The difference was most striking for CD4+ and CD4+ naïve T cells. Reconstitution of B cells and monocytes was comparable between groups. T cells appeared equally functional in both groups among patients without graft-versus-host disease. Our results suggest that the clinical outcomes were not compromised by the early delayed immune reconstitution following haploidentical transplantation.

Keywords

Immune reconstitution haploidentical HLA-identical hematopoietic stem cell transplantation 

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Ying-Jun Chang
    • 1
  • Xiang-Yu Zhao
    • 1
  • Ming-Rui Huo
    • 1
  • Lan-Ping Xu
    • 1
  • Dai-Hong Liu
    • 1
  • Kai-Yan Liu
    • 1
  • Xiao-Jun Huang
    • 1
  1. 1.Peking University People’s Hospital & Institute of HematologyBeijingChina

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