Journal of Clinical Immunology

, Volume 32, Issue 1, pp 78–81 | Cite as

Utility of Screening for Chronic Granulomatous Disease in Patients with Inflammatory Bowel Disease

  • Preeti Jaggi
  • Rebecca Scherzer
  • Rose Knieper
  • Hayat Mousa
  • Vinay Prasad
Article

Abstract

Chronic granulomatous disease (CGD), a genetically heterogeneous primary X-linked or autosomal recessive immunodeficiency, can manifest with gastrointestinal symptoms, including colitis or Crohn’s disease. The frequency of CGD carriers among those with chronic colitis/inflammatory bowel disease is unknown. We underwent a pilot study examining the value of prospectively screening patients with chronic colitis/inflammatory bowel disease (IBD) for either CGD or the carrier state of CGD. No carriers of CGD or patients with CGD were detected among 120 patients. Three patients had inconclusive results and the assay was normal on repeat testing. We conclude that routine screening for CGD was not instructive in this cohort of chronic colitis or IBD patients.

Keywords

Chronic granulomatous disease inflammatory bowel disease colitis 

Abbreviations

DHR

Dihydrorhodamine assay

CGD

Chronic granulomatous disease

IBD

Inflammatory bowel disease

SLE

Systemic lupus erythematosus

Notes

Acknowledgment

This work was supported by the Children’s Research Institute at Nationwide Children’s Hospital.

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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Preeti Jaggi
    • 1
  • Rebecca Scherzer
    • 2
  • Rose Knieper
    • 1
  • Hayat Mousa
    • 3
  • Vinay Prasad
    • 4
  1. 1.Section of Infectious Diseases and ImmunologyNationwide Children’s HospitalColumbusUSA
  2. 2.Department of PediatricsThe Ohio State University College of MedicineColumbusUSA
  3. 3.Section of GastroenterologyNationwide Children’s HospitalColumbusUSA
  4. 4.Section of PathologyNationwide Children’s HospitalColumbusUSA

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