Journal of Clinical Immunology

, Volume 31, Issue 6, pp 1079–1083

Alterations in Immune Function are Associated with Liver Enzyme Elevation in HIV and HCV Co-infection after Commencement of Combination Antiretroviral Therapy

  • Barbara Anne Cameron
  • Carol R. Emerson
  • Cassy Workman
  • Mark D. Kelly
  • Andrew R. Lloyd
  • Jeffrey J. Post
Article

Abstract

The cause of liver enzyme elevation during combination antiretroviral therapy in people with human immunodeficiency virus and hepatitis C virus co-infection is unclear. We followed 12 subjects (five with alanine transaminase elevation) for 24 weeks after combination antiretroviral therapy commencement. Immune responses against hepatitis C virus, human immunodeficiency virus and other viruses were assessed by interferon-γ ELISpot. Plasma cytokines, chemokines and anti-hepatitis C virus antibody levels were measured. Those with liver enzyme elevation had higher ELISpot responses both against hepatitis C virus non-structural regions and other viral antigens, and their anti-hepatitis C virus antibody levels were consistently higher, suggesting that reconstitution of both hepatitis C virus-specific and non-hepatitis C virus-specific immune responses may be associated with liver transaminase elevation during combination antiretroviral therapy.

Keywords

HCV HIV coinfection T cells hepatitis 

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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Barbara Anne Cameron
    • 1
  • Carol R. Emerson
    • 2
    • 3
    • 6
  • Cassy Workman
    • 4
  • Mark D. Kelly
    • 5
  • Andrew R. Lloyd
    • 1
  • Jeffrey J. Post
    • 2
    • 3
  1. 1.Inflammation and Infection Research Centre, School of Medical SciencesUniversity of New South WalesSydneyAustralia
  2. 2.Department of Infectious Diseases and Albion Street CentrePrince of Wales HospitalRandwickAustralia
  3. 3.Prince of Wales Clinical SchoolUniversity of New South WalesRandwickAustralia
  4. 4.AIDS Research InitiativeDarlinghurstAustralia
  5. 5.Brisbane Sexual Health and HIV ServiceBrisbaneAustralia
  6. 6.Royal Victoria HospitalBelfast TrustBelfastNorthern Ireland

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