Journal of Clinical Immunology

, Volume 30, Issue 5, pp 628–631 | Cite as

Molecular Mechanism of NLRP3 Inflammasome Activation

Article

Abstract

The inflammasome is an intracellular multimolecular complex that controls caspase-1 activity in the innate immune system. NLRP3, a member of the NLR family of cytosolic pattern recognition receptors, along with the adaptor protein ASC, mediates caspase-1 activation via assembly of the inflammasome in response to various pathogen-derived factors as well as danger-associated molecules. The active NLRP3 inflammasome drives innate immune response towards invading pathogens and cellular damage, and regulates adaptive immune response. Here, we review identified agonists of the NLRP3 inflammasome and the molecular mechanism by which they induce NLRP3 inflammasome activation. Three signaling pathways involving potassium efflux, generation of reactive oxygen species, and cathepsin B release are discussed.

Keywords

NLRP3 inflammasome agonist potassium efflux reactive oxygen species cathepsin B 

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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Department of ImmunobiologyYale University School of MedicineNew HavenUSA
  2. 2.Department of Immunobiology and Howard Hughes Medical InstituteYale University School of MedicineNew HavenUSA

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