Journal of Clinical Immunology

, Volume 30, Issue 2, pp 185–195

The IL-17 Family Cytokines in Immunity and Disease

  • Rajita Pappu
  • Vladimir Ramirez-Carrozzi
  • Naruhisa Ota
  • Wenjun Ouyang
  • Yan Hu
Article
  • 797 Downloads

Abstract

Introduction

Accumulating evidence suggests that the interleukin (IL)-17 cytokines are major players in the immune response to foreign pathogens. In addition, the pathogeneses of a number of inflammatory diseases have been linked to uncontrolled expression of these cytokine pathways.

Discussion

Genetic and biochemical analyses have elucidated the cellular and molecular events triggered by these proteins during an inflammatory response. While significant efforts have been placed on understanding the functions of IL-17A, IL-17F, and IL-17E, the significance of the other family members, IL-17B−D, in inflammation remains to be determined.

Conclusion

This review will focus on the cellular sources, target cell/receptors that are utilized by these cytokines to control pathogenesis, and the therapeutic potential of targeting these pathways to treat inflammatory disorders.

Keywords

IL-17 IL-17 receptors cytokines host defense autoimmunity inflammation 

Abbreviations

RA

rheumatoid arthritis

MS

multiple sclerosis

IBD

inflammatory bowel disease

NKT

natural killer T

S. aureus

Staphylococcus aureus

M. tuberculosis

Mycobacterium tuberculosis

CIA

collagen-induced arthritis

EAE

experimental autoimmune encephalomyelitis

DSS

dextran sulfate sodium

N. brasiliensis

Nippostrongylus brasiliensis

MOG

myelin oligodendrocyte glycoprotein

DC

dendritic cell

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Rajita Pappu
    • 1
  • Vladimir Ramirez-Carrozzi
    • 1
  • Naruhisa Ota
    • 1
  • Wenjun Ouyang
    • 1
  • Yan Hu
    • 1
  1. 1.Department of ImmunologyGenentech, Inc.South San FranciscoUSA

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