Journal of Clinical Immunology

, Volume 29, Issue 4, pp 461–469 | Cite as

Effect of Arsenic on Regulatory T Cells

  • B. Hernández-Castro
  • L. M. Doníz-Padilla
  • M. Salgado-Bustamante
  • D. Rocha
  • M. D. Ortiz-Pérez
  • M. E. Jiménez-Capdeville
  • D. P. Portales-Pérez
  • A. Quintanar-Stephano
  • R. González-Amaro
Article

Abstract

Introduction

Arsenic (As) affects the function and survival of lymphocytes, and some arsenic compounds exert a relevant antineoplastic effect. We have explored the effect of As on T regulatory cells.

Results and Discussion

In vitro experiments with peripheral blood mononuclear cells from healthy subjects showed that low concentrations of As tended to increase the number of natural T regulatory (nTreg) lymphocytes, whereas concentrations >5.0 μM had an opposite effect. Furthermore, rats exposed to As showed redistribution of nTreg cells, and As administration to rats with experimental allergic encephalomyelitis increased the levels of nTreg cells in spleen and diminished the severity of this condition. On the other hand, in 47 apparently healthy subjects chronically exposed to As, we found significant inverse correlation between urinary As levels and the number and function of nTreg lymphocytes. Although most of these individuals showed enhanced levels of apoptotic lymphocytes in peripheral blood, with a diminution of mitochondrial membrane potential, no significant correlation between these parameters and urinary As was detected.

Conclusion

Our data indicate that As seems to have a relevant and complex effect on nTreg cells.

Keywords

T lymphocytes apoptosis immunoregulation cytokines immunosuppression 

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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • B. Hernández-Castro
    • 1
  • L. M. Doníz-Padilla
    • 1
  • M. Salgado-Bustamante
    • 1
  • D. Rocha
    • 2
  • M. D. Ortiz-Pérez
    • 3
  • M. E. Jiménez-Capdeville
    • 3
  • D. P. Portales-Pérez
    • 4
  • A. Quintanar-Stephano
    • 5
  • R. González-Amaro
    • 1
  1. 1.Department of Immunology, Facultad de MedicinaUASLPSan Luis PotosíMéxico
  2. 2.Department of Environmental Toxicology, Facultad de MedicinaUASLPSan Luis PotosíMéxico
  3. 3.Department of Biochemistry, Facultad de MedicinaUASLPSan Luis PotosíMéxico
  4. 4.Laboratory of Cellular and Molecular Immunology, Facultad de Ciencias QuímicasUASLPSan Luis PotosíMéxico
  5. 5.Laboratory of NeuroimmunoendocrinologyCentro de Ciencias Básicas, UAAAguascalientesMéxico

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