Journal of Clinical Immunology

, Volume 29, Issue 3, pp 247–256

Cytokine-Producing Dendritic Cells in the Pathogenesis of Inflammatory Skin Diseases

  • Leanne M. Johnson-Huang
  • N. Scott McNutt
  • James G. Krueger
  • Michelle A. Lowes
Article

DOI: 10.1007/s10875-009-9278-8

Cite this article as:
Johnson-Huang, L.M., McNutt, N.S., Krueger, J.G. et al. J Clin Immunol (2009) 29: 247. doi:10.1007/s10875-009-9278-8

Abstract

Introduction

Inflammatory skin diseases can be examined from many viewpoints. In this review, we consider three distinct cutaneous inflammatory diseases from the point of view of their major lesional dendritic cell (DC) subpopulations. The DC populations considered are Langerhans cells, myeloid DCs, and plasmacytoid DCs (pDCs), with specific attention to the presence and role of the inflammatory counterparts of these cells. From such a “dendritic cell-centric” focus, psoriasis, atopic dermatitis (AD), and cutaneous lupus erythematosus (CLE) are explored.

Discussion

In psoriasis, there is a specific population of myeloid “inflammatory” DCs that appears to play an important pathogenic role, while pDCs have been recently implicated in the initiation of psoriatic lesions. In AD, Langerhans cells may be important during initiation, while “inflammatory dendritic epidermal cells” (IDECs) appear to be abundant in lesional epidermis and dermis and contribute to maintenance of AD. These IDECs may actually be analogous to the myeloid inflammatory DCs found in the epidermal and dermal compartments of the skin in psoriasis, although they express distinct surface markers and induce different T cell polarities as a result of different cytokine milieu in which they develop. CLE has been recently characterized as a type I IFN-mediated disease, and pDCs are integral to the pathogenesis of this disease.

Conclusion

Thus, these DC subpopulations and their products will be reviewed in the context of these three cutaneous diseases to provide clinico-pathophysiological correlations between the lesional DCs, their products, and the skin diseases.

Keywords

Dendritic cell cytokine skin inflammation psoriasis atopic dermatitis 

Abbreviations

DC

Dendritic cells

IDECs

inflammatory dendritic epidermal cells

pDCs

plasmacytoid dendritic cells

AD

atopic dermatitis

CLE

cutaneous lupus erythematosus

TNF

tumor necrosis factor

iNOS

inducible nitric oxide synthase

NO

nitric oxide

TIP-DCs

TNF- and iNOS-producing dendritic cells

TLSP

thymic stromal lymphopoietin

TSLPR

thymic stromal lymphopoietin receptor

LCs

Langerhans cells

SLE

systemic lupus erythematosus

MxA

myxovirus protein A

ICAM-1

intercellular adhesion molecule-1

Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Leanne M. Johnson-Huang
    • 1
  • N. Scott McNutt
    • 1
  • James G. Krueger
    • 1
  • Michelle A. Lowes
    • 1
  1. 1.Laboratory for Investigative DermatologyThe Rockefeller UniversityNew YorkUSA

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