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Journal of Clinical Immunology

, Volume 29, Issue 2, pp 205–209 | Cite as

An Association Study of 13 SNPs from Seven Candidate Genes with Pediatric Asthma and a Preliminary Study for Genetic Testing by Multiple Variants in Taiwanese Population

  • Jiu-Yao Wang
  • Ya-Huei Liou
  • Ying-Jye Wu
  • Ya-Hsin Hsiao
  • Lawrence Shih-Hsin WuEmail author
Article

Abstract

Introduction

Asthma is one of the most common chronic diseases in children. It is caused by complex interactions between various genetic factors and exposures to environmental allergens and irritants. Because of the heterogeneity of the disease and the genetic and cultural differences among different populations, a proper association study and genetic testing for asthma and susceptibility genes is difficult to perform.

Materials and Methods

We assessed 13 single-nucleotide polymorphisms (SNPs) in seven well-known asthma susceptibility genes and looked for association with pediatric asthma using 449 asthmatic subjects and 512 non-asthma subjects in Taiwanese population.

Results

CD14-159 C/T and MS4A2 Glu237Gly were identified to have difference in genotype/allele frequencies between the control group and asthma patients. Moreover, the genotype synergistic analysis showed that the co-contribution of two functional SNPs was riskier or more protective from asthma attack. Our study provided a genotype synergistic method for studying gene–gene interaction on polymorphism basis and genetic testing using multiple polymorphisms.

Keywords

Pediatric asthma SNPs genetic testing asthma susceptibility genes 

Supplementary material

10875_2008_9256_MOESM1_ESM.doc (361 kb)
ESM Supplement Table 1 The highest frequencies two subgroups of total nine subgroups and the results for comparing to sum of other subgroups by χ 2 test (DOC 361 KB)

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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Jiu-Yao Wang
    • 1
  • Ya-Huei Liou
    • 2
  • Ying-Jye Wu
    • 2
  • Ya-Hsin Hsiao
    • 2
  • Lawrence Shih-Hsin Wu
    • 2
    Email author
  1. 1.Department of Pediatrics and Institute of Molecular Medicine, College of MedicineNational Cheng-Kung UniversityTainanTaiwan
  2. 2.Research and Product Development DivisionVita Genomics Inc.Wugu ShiangTaiwan

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